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Improving Alzheimer's disease by altering gut microbiota in tree shrews with ginsenoside Rg1

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收录情况： ◇ SCIE

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机构： [1]Deparment of Laboratory Animal Science, Kunming Medical University, Kunming, Yunnan, China, [2]Instituteof Molecular Clinical Medicine, Kunming Medical Univercity, Kunming, Yunnan, China, [3]Technology TransferCenter, Kunming Medical University, Kunming, Yunnan, China [4]Department of Emergency Medicine, theFirst Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

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关键词： Alzheimer's disease ginsenoside Rg1 gut microbiota Morris water maze tau protein tree shrew

摘要：

Ginsenoside Rg1 (GRg1) has neuroprotective effects on Alzheimer's disease (AD). The occurrence and progression of AD are closely related to gut microbiota. Few studies have learned the direct relationship between GRg1 and gut microbiota. In this study, we found an original way to research this relationship by using GRg1 in the AD model of tree shrews. Morris water maze and immunohistochemistry were performed to test the cognition repairing function of GRg1 by tree shrews and 16S ribosomal RNA sequencing was used to explore the composition and abundance of gut microbiota. After GRg1 treatment, the result of Morris water maze showed an improvement in cognitive function, and immunohistochemistry revealed a decrease in tau protein. Moreover, 16SrRNA sequencing results showed the abundances of Proteobacteria and Verrucomicrobia were significantly different, and Lactobacillaceae was significantly increased in the GRg1 treatment group. It also showed that the gut microbiome with middle and high doses of GRg1 was close to the normal group. In conclusion, this study suggests that GRg1 at middle and high doses may change the abundance of gut microbiota to improve AD, and thatProteobacteria and Verrucomicrobia are key microbiota. This is the first report that has ever studied the relationship between GRg1 and gut microbiota in tree shrews. © 2020 FEMS.

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出版当年[2020]版：

大类 | 4 区生物

小类 | 4 区微生物学

最新[2023]版：

大类 | 4 区生物学

小类 | 4 区微生物学

JCR分区：

出版当年[2019]版：

Q3 MICROBIOLOGY

最新[2023]版：

Q3 MICROBIOLOGY

影响因子： 2.2 最新[2023版] 2.6 最新五年平均 1.987 出版当年[2019版] 2.233 出版当年五年平均 1.994 出版前一年[2018版] 2.742 出版后一年[2020版]

第一作者：

第一作者机构： [1]Deparment of Laboratory Animal Science, Kunming Medical University, Kunming, Yunnan, China,

通讯作者：

通讯机构： [1]Deparment of Laboratory Animal Science, Kunming Medical University, Kunming, Yunnan, China, [3]Technology TransferCenter, Kunming Medical University, Kunming, Yunnan, China [*1]Kunming Medical University, 1168 West Chunrong Road, Chenggong, Kunming, Yunnan 650500, P.R. China.

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