机构：[a]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, PR China[b]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, PR China昆明医科大学附属第一医院[c]Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, PR China
Genome-wide association studies suggest that rs1064395 in the neurocan gene (NCAN) is a potential risk factor for bipolar disorder (BPD), and further replication analyses in larger independent samples are needed. We herein analyzed rs1064395 in a Han Chinese sample of 1,146 BPD cases and 2,031 controls, followed by a meta-analysis of BPD samples from worldwide populations including a total of 15,318 cases and 91,990 controls. The meta-analysis found that rs1064395 showed a genome-wide significant association with BPD (p = 4.92 × 10-9, OR = 1.126 for the A allele), although it did not reach the significance level in the Han Chinese sample (p = 0.415, OR = 1.070 for the A allele). We also examined the association between the single nucleotide polymorphisms and major depressive disorder (MDD) given the presumed genetic overlap between BPD and MDD, and rs1064395 was also associated with MDD (p = 0.0068, OR = 1.067 for the A allele) in a meta-analysis of 14,543 cases and 14,856 controls. Our data provide further evidence for the involvement of NCAN in the genetic susceptibility to BPD and also implicate its broader role in major mood disorders.
基金：
This study was supported by the National Natural Science Foundation of China (grant numbers 81722019 to M.L., 31701133 to X.X., 31701088 to L.L.); the Medical and Health Science and Technology Project in Zhejiang (2018KY721); Yunnan Provincial Science and Technology Department - Kunming Medical University Joint Applied Basic Research Project (2015FB031) and Health Science and Technology Plan projects in Yunnan Province (2017NS028) to W. Liu; and Research Foundation of West China Psychiatric Association to F. Liu.
语种：
外文
PubmedID：
第一作者：
第一作者机构：[a]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, PR China
共同第一作者：
通讯作者：
通讯机构：[a]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, PR China[c]Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, PR China[*1]Department of Psychiatry, Ningbo Kangning Hospital,1 Zhuang-yu Nanlu Ningbo, Zhejiang 315201 (PR China)[*2]Kunming Institute of Zoology, Chinese Academy of Sciences,32 Jiao-chang Donglu,Kunming, Yunnan 650223 (PR China)
推荐引用方式(GB/T 7714)：
Lu Wang,Weiqing Liu,Xingxing Li,et al.Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder.[J].Molecular neuropsychiatry.2018,4(1):30-34.doi:10.1159/000488590.
APA：
Lu Wang,Weiqing Liu,Xingxing Li,Xiao Xiao,Lingyi Li...&Ming Li.(2018).Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder..Molecular neuropsychiatry,4,(1)
MLA：
Lu Wang,et al."Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder.".Molecular neuropsychiatry 4..1(2018):30-34
