高级检索
当前位置: 首页 > 详情页

ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling

文献详情

资源类型:
WOS体系:

收录情况: ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

机构: [1]Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China [2]Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China [3]Fudan Univ, Inst Brain Sci, MOE Frontiers Ctr Brain Sci, Shanghai 200032, Peoples R China [4]Guangdong Med Univ, Affiliated Hosp, Zhanjiang 524001, Peoples R China [5]Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650223, Yunnan, Peoples R China [6]Tongji Univ, Sch Med, East Hosp, Key Lab Arrhythmias,Minist Educ China, Shanghai 200092, Peoples R China [7]Tongji Univ, Sch Med, Dept Anat & Neurobiol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China [8]Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650203, Yunnan, Peoples R China [9]Fundan Univ, Dept Lab Anim Sci, Shanghai 200032, Peoples R China [10]Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China [11]Kunming Univ Sci & Technol, Affiliated Hosp KMUST, Med Fac, Dept Clin Lab, Kunming 650032, Yunnan, Peoples R China
出处:
ISSN:

关键词: ZC4H2 RNF220 spinal cord patterning Gli signaling

摘要:
ZC4H2 encodes a C4H2 type zinc-finger nuclear factor, the mutation of which has been associated with disorders with various clinical phenotypes in human, including developmental delay, intellectual disability and dystonia. ZC4H2 has been suggested to regulate spinal cord patterning in zebrafish as a co-factor for RNF220, an ubiquitin E3 ligase involved in Gli signaling. Here we showed that ZC4H2 and RNF220 knockout animals phenocopy each other in spinal patterning in both mouse and zebrafish, with mispatterned progenitor and neuronal domains in the ventral spinal cord. We showed evidence that ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling in vivo. Our data providesnew insights into the possible etiology of the neurodevelopmental impairments observed in ZC4H2-associated syndromes.

基金:
语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2020]版:
大类 | 2 区 生物
小类 | 3 区 细胞生物学
最新[2023]版:
大类 | 2 区 生物学
小类 | 3 区 细胞生物学
JCR分区:
出版当年[2019]版:
Q2 CELL BIOLOGY
最新[2023]版:
Q2 CELL BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者:
第一作者机构: [1]Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China
共同第一作者:
通讯作者:
通讯机构: [1]Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China [2]Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China [3]Fudan Univ, Inst Brain Sci, MOE Frontiers Ctr Brain Sci, Shanghai 200032, Peoples R China [6]Tongji Univ, Sch Med, East Hosp, Key Lab Arrhythmias,Minist Educ China, Shanghai 200092, Peoples R China [7]Tongji Univ, Sch Med, Dept Anat & Neurobiol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China [9]Fundan Univ, Dept Lab Anim Sci, Shanghai 200032, Peoples R China [10]Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:82587 今日访问量:0 总访问量:681 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 云南省第一人民医院 技术支持:重庆聚合科技有限公司 地址:云南省昆明市西山区金碧路157号