机构:[1]Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China,[2]Department of Neurosurgery, PLA 956th Hospital, Linzhi, China,[3]Department of Neurosurgery, First People’s Hospital of Honghe City, Yunnan, China,[4]Department of Function, The People’s Hospital of Weiyuan County, Sichuan, China,[5]Department of Neurosurgery, The General Hospital of Southern Theater Command PLA, Guangzhou, China
Objective Chronic subdural hematoma (CSDH) is a common disease. Atorvastatin calcium can increase CSDH absorption. However, whether atorvastatin can increase hematoma absorption and reduce recurrence at high altitudes is not clear. Methods After burr-hole drainage, CSDH patients were divided into an atorvastatin group and a control group. Follow-up computed tomography (CT) was performed on day 1, months 1, 2, and 3 after surgery. Then, the recurrence rate, poor therapeutic effect, time to recurrence, poor surgical result, recurrence with operation, CSDH volume, and Markwalder grading scale score (MGSS) were calculated, and related risk factors were analyzed. Results The non-recurrent and recurrent patients in the control group differed significantly in terms of the hemoglobin concentration (HB) [176.24 +/- 16.43 vs. 194.25 +/- 12.34 (g/L),p< 0.01], CT value [41.92 +/- 10.76 vs. 34.12 +/- 8.78 (Hu),p< 0.01], and low-density time [3.88 +/- 1.04 vs. 5.50 +/- 0.87 (d),p< 0.01]. The non-recurrent and recurrent patients in the atorvastatin group differed significantly in terms of the HB [172.66 +/- 16.41 vs. 190.45 +/- 10.23 (g/L),p< 0.01], CT value [38.91 +/- 7.16 vs. 29.50 +/- 8.61 (Hu),p< 0.01], and mixed [2 vs. 4 (n),p< 0.05] and low-density time [4.09 +/- 0.75 vs. 5.45 +/- 1.12 (d),p< 0.01]. The logistic regression analysis showed that HB [odds ratio, 1.14; 95% confidence interval (CI), 1.04-1.25 in the control group, odds ratio, 1.13; 95% CI, 1.03-1.23 in the atorvastatin group] and low-density time (odds ratio, 3.53; 95% CI, 1.42-8.74 in the control group, odds ratio, 2.53; 95% CI, 1.10-5.80 in the atorvastatin group) were possible risk factors for the two groups. The receiver operating characteristic curves showed that the area under the receiver operating characteristic curve values for the HB, CT value (Hu), and low-density time were 0.812, 0.702, and 0.755 for all subjects; 0.812, 0.719, and 0.790 for the control group; and 0.807, 0.682, and 0.756 for the atorvastatin group, respectively. The postoperative follow-up results showed that there was no significant difference in the recurrence rate, poor therapeutic effect, time to recurrence, poor surgical result, recurrence with operation, CSDH volume, or MGSS between the two groups. Conclusion The effect of atorvastatin was not significant after the operation. The risk factors for CSDH recurrence were the HB and low-density time. The HB was the most specific and sensitive predictor of CSDH recurrence.
基金:
This work was supported by Grant No. SWH2017JSZD07 to LW
from the First Affiliated Hospital of Army Medical University
“Science and Technology Innovation Program,” Grant Nos.
81873754 and 81571116 to GZ from the National Natural Science
Foundation of China.
第一作者机构:[1]Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China,[2]Department of Neurosurgery, PLA 956th Hospital, Linzhi, China,
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Wei Linjie,Lin Chi,Zhong Mingfeng,et al.Hemoglobin Concentration May Affect the Effect of Atorvastin on Chronic Subdural Hematoma After Burr-Hole Drainage at High Altitude[J].FRONTIERS IN NEUROSCIENCE.2020,14:doi:10.3389/fnins.2020.00503.
APA:
Wei, Linjie,Lin, Chi,Zhong, Mingfeng,Zhang, Jianbo&Zhu, Gang.(2020).Hemoglobin Concentration May Affect the Effect of Atorvastin on Chronic Subdural Hematoma After Burr-Hole Drainage at High Altitude.FRONTIERS IN NEUROSCIENCE,14,
MLA:
Wei, Linjie,et al."Hemoglobin Concentration May Affect the Effect of Atorvastin on Chronic Subdural Hematoma After Burr-Hole Drainage at High Altitude".FRONTIERS IN NEUROSCIENCE 14.(2020)