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KRAS SNPs are related to colorectal cancer susceptibility and survival in Chinese people

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Liu, XiuLan[1] * ; Yang, Guangji[2] * ; Huang, Juan[3] ; Chai, Li[3] ; Liu, Xun[3] ; Dai, Qiong[4] ; Yang, ZhiHui[3] ;
机构： [1]Department of Pathology, Second People’s Hospital of Neijiang, Neijiang, 641100 Sichuan, PR China [2]Department of Gynecology, First People’s Hospital of Yunnan Province, Kunming, 650032 Yunnan, PR China [3]Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000 Sichuan, PR China [4]Department of Human Anatomy, Southwest Medical University, Luzhou, 646000 Sichuan, PR China
出处：
DOI： 10.2217/bmm-2019-0172
ISSN：

关键词： 3 ' UTR Chinese people colorectal cancer KRAS mRNA prognosis protein relation SNPs susceptibility

摘要：
Aim:KRAS SNPs may increase KRAS transcription and KRAS levels. SNPs of KRAS 3 ' UTR can affect carcinoma risk and prognosis. Materials & methods: The rs8720 and rs7960917 in KRAS 3 ' UTR for colorectal carcinoma (CRC) risk and survival were investigated in a case-control study. Association between SNPs and CRC risk, survival analysis were analyzed by an unconditional logistic regression model, log-rank test, Kaplan-Meier estimation, Cox regression model and one-way analysis of variance. Results & conclusion: The genotype CT of rs8720 was significantly increased risk of CRC, decreased overall survival and event-free survival, and KRAS mRNA and protein expressions were significantly increased in individuals with rs8720 CT, TT genotype. rs8720 may be an important factor in CRC development and prognosis.

基金：
This study was supported by the Project of Department of technology of Sichuan and Southwest Medical University (2017LZXNYDT04).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 4 区 医学：研究与实验
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验
JCR分区：
出版当年[2019]版：
Q3 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Pathology, Second People’s Hospital of Neijiang, Neijiang, 641100 Sichuan, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liu XiuLan,Yang Guangji,Huang Juan,et al.KRAS SNPs are related to colorectal cancer susceptibility and survival in Chinese people[J].BIOMARKERS IN MEDICINE.2020,14(1):13-22.doi:10.2217/bmm-2019-0172.
APA：
Liu, XiuLan,Yang, Guangji,Huang, Juan,Chai, Li,Liu, Xun...&Yang, ZhiHui.(2020).KRAS SNPs are related to colorectal cancer susceptibility and survival in Chinese people.BIOMARKERS IN MEDICINE,14,(1)
MLA：
Liu, XiuLan,et al."KRAS SNPs are related to colorectal cancer susceptibility and survival in Chinese people".BIOMARKERS IN MEDICINE 14..1(2020):13-22

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