机构：[1]Medical School, Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China.[2]Department of Endocrinology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China.内科片内分泌科云南省第一人民医院[3]Reproductive Medicine Center, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, People’s Republic of China门急诊片生殖医学科云南省第一人民医院
Objective The objective ofthis study was to assess the association between thyroid hormone (TH) levels in follicular fluid (FF) and serum and to determine whether THs impact assisted reproductive technology (ART) outcomes. Methods This study enrolled 299 women undergoing ART. Blood samples were drawn on the day of human chorionic gonadotrophin (HCG) administrationand analysed for thyroid-stimulating hormone (TSH), thyroxine(T4), triiodothyronine(T3),free T4 (fT4),free T3(fT3), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) levels. FF was obtained on the oocyte pick up (OPU) day and analysed forTSH, T4, T3, fT4, fT3, TPOAb, TgAb and estradiol levels. Results (1) There were significant positive correlations between serum and FF TH and thyroid autoantibody levels. Statistically significant differences were discovered in serum and FF levels of TSH (p <= 0.001), T4 (p <= 0.001), T3 (p <= 0.001), TPOAbs (p <= 0.001) and TGAbs (p = 0.021). (2) Serum T4 levels [121.9(104.8,140.8) vs 114.1(98.6,130.6) nmol/l, p = 0.026], serum fT4 levels[(19.0(17.7,21.8) vs 18.6(17.0,20.1) pmol/l, p = 0.026], serum T4/T3 ratios [62.5 (55.7, 66.2) vs 59.4 (53.4, 64.9), p = 0.029], FF fT4 levels [19.0(17.5,21.3) vs 18.1(16.8,19.9) pmol/l, p = 0.009] and FF T4/T3 ratios [52.6 (46.4, 57.3) vs 50.0 (43.7, 53.1), p = 0.004] were significantly higher in the successful pregnancy group than the implantation failure group. (3) Spearman's rank correlation analysis revealed positive associations of both the FF T4/T3 ratio and serum TSH levels with the numbers of retrieved oocytes (total or MII) and embryos (fertilized, cleavage, and good quality). Conclusions TH levels in FF are strongly correlated with those in serum on the HCG day, and THs on the HCG day may affect ART outcomes.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China [81760143]; Foundation for High-level Talents of Yunnan, China [L-201624]; Science and Technology Program of Yunnan, China [U0120170150]
第一作者机构：[1]Medical School, Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China.[2]Department of Endocrinology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China.
通讯作者：
通讯机构：[1]Medical School, Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China.[2]Department of Endocrinology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China.
推荐引用方式(GB/T 7714)：
Cai Yun Ying,Lin Na,Zhong Lan Ping,et al.Serum and follicular fluid thyroid hormone levels and assisted reproductive technology outcomes[J].REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY.2019,17(1):doi:10.1186/s12958-019-0529-0.
APA：
Cai, Yun Ying,Lin, Na,Zhong, Lan Ping,Duan, Hui Juan,Dong, Yun Hua...&Su, Heng.(2019).Serum and follicular fluid thyroid hormone levels and assisted reproductive technology outcomes.REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,17,(1)
MLA：
Cai, Yun Ying,et al."Serum and follicular fluid thyroid hormone levels and assisted reproductive technology outcomes".REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 17..1(2019)
