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Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway

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收录情况： ◇ SCIE

作者：
Liang, Yueyang[1] * ; Wang, Shushu[2] ; Liu, Jia[3,*1] ;
机构： [1]Department of Breast Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China [2]Department of Breast & Thyroid Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China [3]Department of Breast & Thyroid Surgery, The First People's Hospital of Yunnan Province, Kunming, China
出处：
DOI： 10.4048/jbc.2019.22.e21
ISSN：

关键词： Apoptosis Breast neoplasms Cell proliferation Genes p53

摘要：
Purpose: Tumor protein p53-regulated apoptosis-inducing protein 1 (TP53AIP1) functions in various cancers. We studied the effect and molecular mechanism of TP53AIP1 in breast cancer. Methods: The degree of correlation between TP53AIP1 expression and overall survival in patients with breast cancer was obtained from the online The Cancer Genome Atlas database. Six of the TP53AIP1 levels in the tumor and adjacent non-tumor tissues randomly selected from 38 breast cancer patients were determined. Transgenic technology was used to enhance the expression of TP53AIP1 in breast cancer cell lines, MDA-MB-415 and MDA-MB-468, and to observe the effects of gene overexpression on the proliferation, cell cycle, and apoptosis of breast cancer cells. The molecular mechanism of association between cell cycle-and apoptosis-related factors and the phosphoinositide 3-kinases/protein kinase B (PI3K/Akt) pathway was also studied. Results: The messenger RNA and protein expression levels of TP53AIP1 in cancer tissues were significantly lower than those in the control group. TP53AIP1 overexpression inhibits cell viability. The mechanism of TP53AIP1 inhibition of proliferation and growth of breast cancer cells includes cell cycle arrest, apoptosis promotion (p < 0.01), promotion of the expression of cleaved-caspase-3 (p < 0.01), cleaved-caspase-9 (p < 0.01), B cell lymphoma/leukemia-2 (Bcl-2)-associated X protein, and p53 (p < 0.01), and the inhibition of Bcl-2, Ki67, and PI3K/Akt pathways (p < 0.01). Conclusion: TP53AIP1 may be a novel tumor suppressor gene in breast cancer and can potentially be used as an effective target gene for the treatment of breast cancer.

语种：
外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 3 区 医学
小类 | 4 区 肿瘤学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
JCR分区：
出版当年[2018]版：
Q3 ONCOLOGY
最新[2023]版：
Q3 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Breast Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China
通讯作者：
通讯机构： [3]Department of Breast & Thyroid Surgery, The First People's Hospital of Yunnan Province, Kunming, China [*1]Department of Breast & Thyroid Surgery, The First People's Hospital of Yunnan Province, No.157 Jinbi Road, Xishan District, Kunming, 650032, China.
推荐引用方式(GB/T 7714)：
Liang Yueyang,Wang Shushu,Liu Jia.Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway[J].JOURNAL OF BREAST CANCER.2019,22(2):172-184.doi:10.4048/jbc.2019.22.e21.
APA：
Liang, Yueyang,Wang, Shushu&Liu, Jia.(2019).Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway.JOURNAL OF BREAST CANCER,22,(2)
MLA：
Liang, Yueyang,et al."Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway".JOURNAL OF BREAST CANCER 22..2(2019):172-184

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