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Three new diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii

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收录情况： ◇ SCIE

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机构： [1]Department of Clinical Laboratories, The First People’s Hospital of Yunnan Province, Kunming 650032, China [2]Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, China [3]Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, China

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关键词： Diphenyl ethers Phomopsis fukushii anti-MRSA activity

摘要：

Three new diphenyl ethers (1-3), together with four known isopentylated diphenyl ethers derivatives (4-7), were isolated from the fermentation products of an endophytic fungus Phomopsis fukushii. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-3 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed strong inhibitions with inhibition zone diameters (IZD) of 20.2 +/- 2.5mm and 17.9 +/- 2.2mm, respectively. Compound 3 also showed good inhibition with IZD 15.2 +/- 1.8mm. The IZD data of compound 1 is close to that of positive control with IZD 21.9 +/- 2.1mm.

基金：

基金编号： 21462051 21562049 31360081 31400303 110201502006 2015539200340277 2016JC03

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

JCR分区：

出版当年[2018]版：

Q3 CHEMISTRY, APPLIED Q3 PLANT SCIENCES Q4 PHARMACOLOGY & PHARMACY Q4 CHEMISTRY, MEDICINAL

最新[2023]版：

Q3 PLANT SCIENCES Q3 CHEMISTRY, APPLIED Q4 CHEMISTRY, MEDICINAL Q4 PHARMACOLOGY & PHARMACY

影响因子： 1.3 最新[2023版] 1.5 最新五年平均 1.17 出版当年[2018版] 1.199 出版当年五年平均 1.091 出版前一年[2017版] 1.345 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Clinical Laboratories, The First People’s Hospital of Yunnan Province, Kunming 650032, China

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Three new diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii

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