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Gut microbiota alterations from different Lactobacillus probiotic-fermented yoghurt treatments in slow-transit constipation

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机构： [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong, Kunming 650500, Yunnan, China [2]Department of Gastroenterology, First People Hospital of Yunnan Province, Kunming 650032, Yunnan, China [3]Yunnan University of Traditional Chinese Medicine, Kunming 650500, Yunnan, China

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关键词： Constipation Probiotics Yoghurt Functional food Bacterial community

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Constipation is a frequent complaint, and probiotics could have a potentially synergistic effect on intestinal transit. In the present study, yoghurt intake improved the symptoms of slow-transit constipation, which was confirmed in 144 mice (nine groups, n = 16) with loperamide-induced constipation. Yoghurt fermented with different probiotics was administered orally. Loperamide treatment caused a marked increase in first defecation time and a decrease in the charcoal transit ratio (P < 0.05), while loperamide treatment after intake of a new formulation of yoghurt could significantly improve defecation time and intestinal health. Significant (P < 0.001) decreases in butanoic acid content were observed in groups given three different strains of yoghurt. Yoghurt intake could also change the intestinal bacterial community composition, which was supported by operational taxonomic unit-related analysis as well as principal coordinates analysis (PCA). Our results showed conclusive evidence indicating that yogurt is an excellent functional food that improves the symptoms of slow-transit constipation. (C) 2017 Published by Elsevier Ltd.

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出版当年[2017]版：

大类 | 2 区

工程技术

小类 | 1 区食品科技

最新[2025]版：

大类 | 2 区农林科学

小类 | 3 区食品科技 4 区营养学

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出版当年[2016]版：

Q1 FOOD SCIENCE & TECHNOLOGY

最新[2023]版：

Q2 FOOD SCIENCE & TECHNOLOGY Q2 NUTRITION & DIETETICS

影响因子： 3.8 最新[2023版] 4.6 最新五年平均 3.144 出版当年[2016版] 3.46 出版当年五年平均 3.973 出版前一年[2015版] 3.47 出版后一年[2017版]

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第一作者机构： [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong, Kunming 650500, Yunnan, China

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