Clinical application of the combined determination of neutrophil elastase, fetal fibronectin, and cervical length in predicting preterm birth of twin pregnancies
机构：[1]Department of Obstetrics, the First People’s Hospital of Yunnan Province, Kunming, PR China外科片产科云南省第一人民医院[2]Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
In total, 115 pregnant women underwent detection of Neutrophil Elastase (NE) and Fetal Fibronectin (fFN), and measurement of Cervical Length (CL) 20-34 weeks into pregnancy. The clinical value of these values in predicting preterm birth was analysed retrospectively. In the 29 women who gave birth before 34 weeks, the CL value (21.3 +/- 9.8 mm) and the fFN and NE rates (65.5% and 75.9%, respectively) were significantly different compared with women undergoing childbirth after 34 weeks (P < 0.05). The combined detection rate of CL and fFN was 78.6%, CL and NE was 84.4%, and fFN and NE was 88.9%. Moreover, the combined detection rate of CL, NE and fFN was 100%. The predictive value of premature labor in twin pregnancy using multiple markers was more successful than that of a single marker; therefore, these multiple markers could be used to evaluate clinical intervention.
基金：
Culture Program for Reverse Talents of Middle-Young Aged Academic and Technology Leader of Yunnan Province of China [2008PY045]; Yunnan Province Key Program for Applied Fundamental Research [2014FA046]; Yunnan Province Scientific Research Program for Research Center of Environment and Feto-maternal Diseases [2014NS237/2014NS238]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41361086]; Perinatal Medical Innovation Team Project of Yunnan; Iwashita Expert workstation project
第一作者机构：[1]Department of Obstetrics, the First People’s Hospital of Yunnan Province, Kunming, PR China[*1]Department of Obstetrics The First People’s Hospital of Yunnan Province PR China
通讯作者：
通讯机构：[1]Department of Obstetrics, the First People’s Hospital of Yunnan Province, Kunming, PR China[*1]Department of Obstetrics The First People’s Hospital of Yunnan Province PR China
推荐引用方式(GB/T 7714)：
Dong Xudong,Iwashita M.,Ai Fang,et al.Clinical application of the combined determination of neutrophil elastase, fetal fibronectin, and cervical length in predicting preterm birth of twin pregnancies[J].BIOMEDICAL RESEARCH-INDIA.2017,28(10):4688-4695.
APA：
Dong, Xudong,Iwashita, M.,Ai, Fang,Jiang, Jiang,Liu, Huanling&Wu, Yunping.(2017).Clinical application of the combined determination of neutrophil elastase, fetal fibronectin, and cervical length in predicting preterm birth of twin pregnancies.BIOMEDICAL RESEARCH-INDIA,28,(10)
MLA：
Dong, Xudong,et al."Clinical application of the combined determination of neutrophil elastase, fetal fibronectin, and cervical length in predicting preterm birth of twin pregnancies".BIOMEDICAL RESEARCH-INDIA 28..10(2017):4688-4695
