To enhance the management intensity on public health, control the infectious disease spreading and further reduce the incidence rate are significant measures for controlling public paroxysmal diseases infection and stabilizing the society. How to identify the application of public health management system on infectious disease prevention, and to prevent the spread of infectious diseases maximally are worthy of profound research by more scholars. To this end, first of all, the paper described the significance of public health management on infectious disease prevention. Secondly, it further elaborated its orientation. And finally, it proposed prevention measures thus to improve the management efficiency of public health management, and effectively prevent the incidence rate of infectious disease.