机构：[1]Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan Province, China[2]The First People's Hospital of Yunnan Province, Kunming, Yunnan Province, China云南省第一人民医院[3]Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province, China[4]Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, Yunnan Province, China
Context: Naringin is a natural flavanone glycoside that is found in the Chinese herbal medicines and citrus fruits. Studies have demonstrated that naringin possesses numerous biological and pharmacological properties, but few reviews of these studies have been performed. Objective: The present review gathers the fragmented information available in the literature describing the extraction of naringin, its pharmacology and its controlled release formulations. Current research progress and the therapeutic potential of naringin are also discussed. Methods: A literature survey for relevant information regarding the biological and pharmacological properties of naringin was conducted using Pubmed, Sciencedirect, MEDLINE, Springerlink and Google Scholar electronic databases from the year 2007-2015. Results: Naringin modulates signalling pathways and interacts with signalling molecules and thus has a wide range of pharmacological activities, including anti-inflammatory, anti-cancer activities, as well as effects on bone regeneration, metabolic syndrome, oxidative stress, genetic damage and central nervous system (CNS) diseases. Information was gathered that showed the extraction of naringin can be improved using several modifications. There has been some progress in the development of controlled release formulations of naringin. Conclusion: Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required.
基金：
National Scientific Foundation of China under the National Scientific Grant [81160134]; Yunnan Provincial Science and Technology Department under the Grant Talent Reserve of Young Academic and Technical Leaders of Yunnan Province [2012HB027]; Yunnan Provincial Bureau of Health under the Grant Medical Academic Leaders of Yunnan Province [D-201232]
第一作者机构：[1]Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan Province, China[2]The First People's Hospital of Yunnan Province, Kunming, Yunnan Province, China[3]Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province, China
通讯作者：
通讯机构：[1]Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan Province, China[2]The First People's Hospital of Yunnan Province, Kunming, Yunnan Province, China[3]Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province, China[*1]the First People's Hospital of Yunnan Province, Kunming, Yunnan Province, 650032, China
推荐引用方式(GB/T 7714)：
Chen Rui,Qi Qiao-Ling,Wang Meng-Ting,et al.Therapeutic potential of naringin: an overview[J].PHARMACEUTICAL BIOLOGY.2016,54(12):3203-3210.doi:10.1080/13880209.2016.1216131.
APA：
Chen, Rui,Qi, Qiao-Ling,Wang, Meng-Ting&Li, Qi-Yan.(2016).Therapeutic potential of naringin: an overview.PHARMACEUTICAL BIOLOGY,54,(12)
MLA：
Chen, Rui,et al."Therapeutic potential of naringin: an overview".PHARMACEUTICAL BIOLOGY 54..12(2016):3203-3210
