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Amaryllidaceae alkaloids from the bulbs of Lycoris radiata with cytotoxic and anti-inflammatory activities

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收录情况： ◇ SCIE

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机构： [1]Cent S Univ, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China [2]First People Hosp Qujing, Qujing 655000, Yunnan Province, Peoples R China [3]Qujing Med Coll, Qujing 655000, Yunnan Province, Peoples R China

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关键词： Lycoris radiata Amaryllidaceae Alkaloids Cytotcoxicity Anti-inflammatory activity

摘要：

Four new Amaryllidaceae alkaloids, (+)-1-hydroxy-ungeremine (1), (+)-6 beta-acetyl-8-hydroxy-9-methoxy-crinamine (2), (+)-2-hydroxy-8-demethyl-homolycorine-alpha-N-oxide (3), (+)-N-methoxylcarbonyl-2-demethyl-isocorydione (4), together with two known compounds, (+)-6 beta-acetyl-crinamine (5) and 8-demethyl-homolycorine-alpha-N-oxide (6) were isolated from the ethanol extract of the bulbs of Lycoris radiata. Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the isolated alkaloids were in vitro evaluated for their cytotoxic activities against eight tumor cell lines (BEN-MEN-1, CCF-STTG1, CHG-5, SHG-44, U251, BGC-823, HepG2 and SK-OV-3) and anti-inflammatory activities against Cox-1 and Cox-2. As a result, alkaloids 1 and 4 exhibited significant cytotoxic activities against all tested tumor cell lines except against BEN-MEN-1. Additionally, alkaloids 1 and 4 possessed selective inhibition of Cox-2 comparable with the standard drug NS-398 (>90%). (C) 2015 Published by Elsevier B.V.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 4 区药物化学 4 区药学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

JCR分区：

出版当年[2014]版：

Q3 PHARMACOLOGY & PHARMACY Q3 CHEMISTRY, MEDICINAL

最新[2023]版：

Q3 CHEMISTRY, MEDICINAL Q3 PHARMACOLOGY & PHARMACY

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.345 出版当年[2014版] 2.466 出版当年五年平均 2.216 出版前一年[2013版] 2.408 出版后一年[2015版]

第一作者：

第一作者机构： [1]Cent S Univ, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China [2]First People Hosp Qujing, Qujing 655000, Yunnan Province, Peoples R China [*1]The First People Hospital of Qujing, Qujing 655000, Yunnan Province, China.

通讯作者：

通讯机构： [1]Cent S Univ, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China [2]First People Hosp Qujing, Qujing 655000, Yunnan Province, Peoples R China [*1]The First People Hospital of Qujing, Qujing 655000, Yunnan Province, China.

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