机构：[1]School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China[2]Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021, China[3]Key Laboratory of Medicinal Chemistry for Natural Resource Education Ministry, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
A series of novel hybrid compounds between benzofuran and N-aryl piperazine have been synthesized and screened in vitro for anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW-264.7 macrophages and for anticancer activity against three human tumor cell lines. The results demonstrated that derivative 16 not only had inhibitory effect on the generation of NO (IC50 = 5.28 μM), but also showed satisfactory and selective cytotoxic activity against human lung cancer line (A549) and gastric cancer cell (SGC7901) (IC50 = 0.12 μM and 2.75 μM, respectively), which was identified as the most potent anti-inflammatory and anti-tumor agent in this study.
基金：
Natural Science Foundation of China (81460624,
81560620), the Application Basic Research Program of Yunnan Province (2014FZ078, 2014FZ087) and the
Yunnan Province doctoral newcomer Award (YN2015015).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区化学
小类|3 区有机化学
最新[2023]版：
大类|2 区化学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[3]Key Laboratory of Medicinal Chemistry for Natural Resource Education Ministry, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
通讯作者：
推荐引用方式(GB/T 7714)：
Yulu Ma,Xi Zheng,Hui Gao,et al.Design, Synthesis, and Biological Evaluation of Novel Benzofuran Derivatives Bearing N-Aryl Piperazine Moiety[J].Molecules (Basel, Switzerland).2016,21(12):doi:10.3390/molecules21121684.
