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Host-guest inclusion system of oleanolic acid with methyl-beta-cyclodextrin: Preparation, characterization and anticancer activity

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收录情况： ◇ SCIE ◇ EI

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机构： [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China [2]Faculty of Medicine, Kunming University of Science and Technology, Kunming 650500, China [3]Research Centre for Pharmaceutical Care and Quality Management, First People's Hospital of Yunnan Province, Kunming 650500, China

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关键词： Oleanolic acid Methyl-beta-cyclodextrin Inclusion complex Characterization Inclusion behavior Anticancer activity

摘要：

In this study, the solid inclusion complex of oleanolic acid (OA) with methyl-beta-cyclodextrin (M-beta-CD) was prepared and characterized by nuclear magnetic resonance (NMR), X-ray diffraction (XRD), scanning electron microscope (SEM) and differential scanning calorimetry (DSC). The inclusion behaviors of OA/M-beta-CD complex were studied by fluorescence spectroscopy and the Job plot, which indicated a 1:1 inclusion mode between OA and M-beta-CD. The stability constant (Ks) of the complex was 1072.30 +/- 20 M-1 determined by spectral titration at 25 degrees C. Besides, the water solubility of OA was significantly increased to 8.2 mg/mL by inclusion complexation, compared to only ca. 0.012 mu g/mL of free OA. The in vitro cytotoxicity of the inclusion complex was noticeably better than that of native OA with the IC50 values of 8.89, 7.89 and 5.77 mu M on human cancer cell lines HepG2, HT29 and HCT116, respectively, by MTT assay. (C) 2016 Elsevier B.V. All rights reserved.

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出版当年[2016]版：

大类 | 4 区化学

小类 | 4 区物理化学

最新[2023]版：

大类 | 2 区化学

小类 | 3 区物理化学

JCR分区：

出版当年[2015]版：

Q3 CHEMISTRY, PHYSICAL

最新[2023]版：

Q2 CHEMISTRY, PHYSICAL

影响因子： 4 最新[2023版] 3.5 最新五年平均 1.78 出版当年[2015版] 1.683 出版当年五年平均 1.602 出版前一年[2014版] 1.753 出版后一年[2016版]

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第一作者机构： [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China

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通讯机构： [2]Faculty of Medicine, Kunming University of Science and Technology, Kunming 650500, China [3]Research Centre for Pharmaceutical Care and Quality Management, First People's Hospital of Yunnan Province, Kunming 650500, China

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