机构：[1]Faculty of Environmental Science and Engineering[2]Medical Faculty, Kunming University of Science and Technology[3]The Emergency Intensive Care Unit, The First People’s Hospital of Yunnan Province, Kunming, China外科片重症医学科云南省第一人民医院
Sepsis is the main cause of death in critically ill patients, pathogenesis of which is still unclear. The nuclear factor B (NF-B) inflammatory signal pathway mediated by endoplasmic reticulum stress is involved in sepsis. Thioredoxin-1 (Trx-1) is an important protein of regulating oxidative stress. It plays a crucial role in the anti-oxidation, anti-apoptosis, and anti-inflammation. However, the role and the mechanism of Trx-1 in sepsis have not been extensively studied. In the present study, we showed that the survival was longer in sepsis induced by cecal ligation and puncture in Trx-1 overexpression transgenic (Tg) mice compared with wild-type mice. Wet/dry lung weight ratio was decreased in Trx-1 Tg mice. The levels of TNF- and IL-1 in plasma and lung tissue were inhibited in Tg mice. The expressions of glucose-regulated protein 78, inositol-requiring enzyme 1 (IRE1), tumor necrosis factor receptor-associated factor 2, C/EBP homologous protein, NF-B, and inhibitors of NF-B were increased in lung tissue. More importantly, the overexpression of Trx-1 in transgenic mice suppressed NF-B inflammatory signal pathway by inhibiting the activation of molecules involved in ER stress. Our results suggest that Trx-1 may play protective role in extending survival in sepsis by regulating inflammatory response through suppressing ER stress.
基金：
National Natural Science Foundation of China (Nos. 81160162, U1202227), Program
for Innovative Research Team (in Science and Technology) in University of
Yunnan Province (2014), and a grant from the Key Laboratory of Medical Neurobiology,
Kunming University of Science and Technology.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区医学
小类|2 区外科3 区危重病医学3 区血液学3 区外周血管病
最新[2023]版：
大类|3 区医学
小类|3 区血液学3 区外周血管病3 区外科4 区危重病医学
JCR分区：
出版当年[2015]版：
Q1SURGERYQ2PERIPHERAL VASCULAR DISEASEQ2HEMATOLOGYQ2CRITICAL CARE MEDICINE
最新[2023]版：
Q1SURGERYQ2CRITICAL CARE MEDICINEQ2HEMATOLOGYQ2PERIPHERAL VASCULAR DISEASE
第一作者机构：[1]Faculty of Environmental Science and Engineering[2]Medical Faculty, Kunming University of Science and Technology[3]The Emergency Intensive Care Unit, The First People’s Hospital of Yunnan Province, Kunming, China
通讯作者：
通讯机构：[2]Medical Faculty, Kunming University of Science and Technology[*1]Medical Faculty, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, China.
推荐引用方式(GB/T 7714)：
Chen Guobing,Li Xiang,Huang Mengbing,et al.Thioredoxin-1 Increases Survival in Sepsis by Inflammatory Response Through Suppressing Endoplasmic Reticulum Stress[J].SHOCK.2016,46(1):67-74.doi:10.1097/SHK.0000000000000570.
APA：
Chen, Guobing,Li, Xiang,Huang, Mengbing,Li, Mei,Zhou, Xiaoshuang...&Bai, Jie.(2016).Thioredoxin-1 Increases Survival in Sepsis by Inflammatory Response Through Suppressing Endoplasmic Reticulum Stress.SHOCK,46,(1)
MLA：
Chen, Guobing,et al."Thioredoxin-1 Increases Survival in Sepsis by Inflammatory Response Through Suppressing Endoplasmic Reticulum Stress".SHOCK 46..1(2016):67-74
