机构：[1]Department of Hepatobiliary and Pancreatic Surgery, Clinical Medical College of Yangzhou University, Jiangsu, 225001, P.R. China[2]Liver Cancer Institute and Department of Liver Surgery of Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai, 200032, P.R. China[3]Department of Digestion, The First People’s Hospital of Yunnan Province, Yunnan, 650000, P.R. China内科片消化内科云南省第一人民医院
The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. In this study, we found that ubiquitin associated protein 2 (UBAP2) was significantly downregulated in hepatocellular carcinoma (HCC) tissues compared with adjacent normal tissues. Furthermore, higher expression of UBAP2 in cancer tissues was correlated with good prognosis in HCC patients. Knockdown of UBAP2 significantly enhanced the invasion and proliferation of HCC cells in vitro and promoted tumor growth in vivo, while enforced expression of UBAP2 impaired the aggressive ability and tumor growth of HCC cells. Mechanistically, UBAP2 formed a complex with Annexin A2 and promoted the degradation of Annexin A2 protein by ubiquitination, and then inhibited HCC progression. Collectively, UBAP2 appears as a novel marker for predicting prognosis and a therapeutic target for HCC.
基金：
This study was supported by the National Key Sci-Tech Project (2012ZX10002011-002), the National Natural Science Foundation of China (81472840, 81172023, 81160062 and 81071741) and the Shanghai Municipal Natural Science Foundation (14ZR1405800, 11ZR1428300, 114119a5000), Six talent peaks project in Jiangsu Province (2014-WSW-076), Medical academic technology leaders project of Yangzhou, the fourth phase of the “333 project” in Jiangsu Province (BRA2015188).
第一作者机构：[1]Department of Hepatobiliary and Pancreatic Surgery, Clinical Medical College of Yangzhou University, Jiangsu, 225001, P.R. China[2]Liver Cancer Institute and Department of Liver Surgery of Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai, 200032, P.R. China
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推荐引用方式(GB/T 7714)：
Bai Dou-Sheng,Wu Chao,Yang Liu-Xiao,et al.UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2[J].ONCOTARGET.2016,7(22):32946-32955.doi:10.18632/oncotarget.8783.
APA：
Bai, Dou-Sheng,Wu, Chao,Yang, Liu-Xiao,Zhang, Chi,Zhang, Peng-Fei...&Shi, Guo-Ming.(2016).UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2.ONCOTARGET,7,(22)
MLA：
Bai, Dou-Sheng,et al."UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2".ONCOTARGET 7..22(2016):32946-32955
医学