机构：[1]Department of Orthodontics, the AffiliatedStomatology Hospital of Kunming MedicalUniversity, Kunming 650031, China[2]Department of Dental Diorthosis, The FirstPeople’s Hospital of Yunnan Province,Kunming 650032, China[3]Department of OralAnatomy and Physiology, School ofStomatology, Kunming Medical University,Kunming 650031, China
Unilateral fracture of the condylar neck in immature subjects might lead to mandible asymmetry and condyle remodelling. A rat model was used to investigate mandibular deviation and condylar remodelling associated with condyle fracture. 72 4-week-old male rats were randomly divided into three groups: an experimental group (unilateral transverse condylar fracture induced surgically), a sham operation group (surgical exposure but no fracture), and a non-operative control group (no operation). The rats were killed at intervals up to 9 weeks after surgery, and outcomes were assessed using various measures of mandible deviation, histological and X-ray observation, and immunohistochemical measures of expression levels of connective tissue growth factor (CTGF) and type II collagen (Col II). The fracture led to the degeneration of mandibular size, associated with atrophy of fractured condylar process. Progressive remodelling of cartilage and increasing expression levels of CTGF and Col II were found. The authors conclude that condylar fracture can lead to asymmetries in mandible and condyle remodelling and expression of CTGF and Col II in condylar cartilage on both the ipsilateral and the contralateral sides.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30960426]
第一作者机构：[1]Department of Orthodontics, the AffiliatedStomatology Hospital of Kunming MedicalUniversity, Kunming 650031, China
共同第一作者：
通讯作者：
通讯机构：[3]Department of OralAnatomy and Physiology, School ofStomatology, Kunming Medical University,Kunming 650031, China[*1]Department of Oral Anatomy and Physiology School of Stomatology Kunming Medical University Kunming 650031 China
推荐引用方式(GB/T 7714)：
Hu Y.,Yang H. -F.,Li S.,et al.Condyle and mandibular bone change after unilateral condylar neck fracture in growing rats[J].INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY.2012,41(8):912-921.doi:10.1016/j.ijom.2011.12.036.
APA：
Hu, Y.,Yang, H. -F.,Li, S.,Chen, J. -z.,Luo, Y. -w.&Yang, C..(2012).Condyle and mandibular bone change after unilateral condylar neck fracture in growing rats.INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,41,(8)
MLA：
Hu, Y.,et al."Condyle and mandibular bone change after unilateral condylar neck fracture in growing rats".INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 41..8(2012):912-921
