High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis
机构：[1]Department of Reproductive Endocrinology,Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang浙江大学医学院附属妇产科医院[2]Department of Reproductive Endocrinology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, People’s Republic of China内科片内分泌科云南省第一人民医院
Objective: To investigate the possible roles of cyclin B1/cyclin-dependent kinase (cdc2) and Polo-like kinase 1 (Plk1) in the pathogenesis of endometriosis. Design: A case-control study. Setting: University hospital. Patient(s): Patients with or without endometriosis were diagnosed by pathological examination or laparoscopy. The patients with the following criteria within the past 6 months were excluded: endocrine or inflammatory diseases, pregnancy or lactation, hormonal therapy, and neoplasm in the uterine cavity. Intervention(s): Eutopic and ectopic endometria were obtained at the time of surgery. Blood was collected on the same day as surgery. Main Outcome Measure(s): The mRNA/protein expression and localization of cyclin B 1, cdc2, and Plk1 in endometrium, and serum levels of E-2 and P. Result(s): The expression levels of cyclin B1 and Plk1, but not cdc2, in ectopic endometria were significantly higher than in eutopic endometria. The immunohistochemical staining of cyclin B1 and Plk1 was detected in the nuclei of ectopic and eutopic endometrial cells. Furthermore, ectopic endometrial expression levels of cyclin B1 or Plk1 were positively correlated with serum E-2 levels. Conclusion(s): Cyclin B1 and Plk1 may play important roles in the pathogenesis of endometriosis by mediating ectopic endometrial cell proliferation under regulation of ovarian hormones. (Fertil Steril (R) 2009;91:979-87. (C) 2009 by American Society for Reproductive Medicine.)
基金：
National Natural Science Foundation of China
(30670789), National Basic Research Program of China
(2006CB944006, 2006CB504004), Key Research Program of Zhejiang
Province (2006C13078), and Key Research Program of Education of
Zhejiang Province (20061382).
第一作者机构：[1]Department of Reproductive Endocrinology,Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang[2]Department of Reproductive Endocrinology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Reproductive Endocrinology,Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang[*1]Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, 2 Xue Shi Road, Hangzhou, Zhejiang, 310006, People’s Republic of China
推荐引用方式(GB/T 7714)：
Tang Li,Wang Ting-Ting,Wu Yan-Ting,et al.High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis[J].FERTILITY AND STERILITY.2009,91(4):979-987.doi:10.1016/j.fertnstert.2008.01.041.
APA：
Tang, Li,Wang, Ting-Ting,Wu, Yan-Ting,Zhou, Cai-Yun&Huang, He-Feng.(2009).High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis.FERTILITY AND STERILITY,91,(4)
MLA：
Tang, Li,et al."High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis".FERTILITY AND STERILITY 91..4(2009):979-987
医学