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CircRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis(Open Access)

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机构： [1]Department of Reproductive Medicine, Reproductive Medical Centre, The First People’s Hospital of Yunnan Province, No. 157 Jin Bi Road, Kunming, People’s Republic of China. [2]Kunming University of Science and Technology, Kunming, People’s Republic of China.

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关键词： Apoptosis circRNA-UBAP2 miR-382-5p Ovarian cancer Proliferation PRPF8

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Objective: circular RNAs (circRNAs) have been reported to be essential regulators of multiple malignant cancers. However, the functions of circRNAs in ovarian cancer need to be further explored. The aim of our study is to explore the role of circRNA-UBAP2 in ovarian cancer and its mechanism. Results: circRNA-UBAP2 was upregulated in ovarian cancer tissues and cell lines. Knockdown of circRNA-UBAP2 inhibited cell proliferation and promoted cell apoptosis, but circRNA-UBAP2 overexpressed got opposite results. In addition, circRNA-UBAP2 targeted miR-382-5p and downregulated its expression, PRPF8 was a target gene of miR-382-5p. Furthemore, circRNA-UBAP2/miR-382-5p/PRPF8 axis affected the proliferation, apoptosis and cell cycle of ovarian cancer through the mechanism of competing endogenous RNAs (ceRNA). Conclusion: circRNA-UBAP2 acted as a ceRNA to sponged miR-382-5p, increased the expression level of PRPF8, and prompted proliferation and inhibited apoptosis in ovarian cancer cells. © 2020 The Author(s).

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区生殖生物学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区生殖生物学

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出版当年[2019]版：

Q2 REPRODUCTIVE BIOLOGY

最新[2023]版：

Q1 REPRODUCTIVE BIOLOGY

影响因子： 3.8 最新[2023版] 4.2 最新五年平均 2.989 出版当年[2019版] 2.909 出版当年五年平均 2.469 出版前一年[2018版] 4.234 出版后一年[2020版]

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第一作者机构： [1]Department of Reproductive Medicine, Reproductive Medical Centre, The First People’s Hospital of Yunnan Province, No. 157 Jin Bi Road, Kunming, People’s Republic of China.

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