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lncRNA TUG1 promotes endometrial fibrosis and inflammation by sponging miR-590-5p to regulate Fasl in intrauterine adhesions

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Ai, Y[a] * ; Chen, M[b] ; Liu, J[a] ; Ren, L[a] ; Yan, X[a] ; Feng, Y[a] ;
机构： [a]Department of Obstetrics & Gynecology, The First People's Hospital of Yunnan Province, No. 157 Jinbi Road, Kunming, Yunnan [b]Kunming University of Science and Technology, NO. 727 South Jingming Road, Chenggong District, Kunming, Yunnan
出处：
DOI： 10.1016/j.intimp.2020.106703
ISSN：

关键词： Epithelial-to-mesenchymal transition Inflammation Intrauterine adhesions lncRNA TUG1/miR-590-5p/Fasl axis Proliferation

摘要：
Intrauterine adhesion (IUA) is one of the most common reproductive system diseases in women worldwide. The role of lncRNAs in multiple diseases has been confirmed, but the role and mechanism of lncRNA taurine upregulated gene 1 (TUG1) in the progression of IUA need to be elucidated further. Here, we found that lncRNA TUG1 was upregulated in the endometrial tissues of IUA and TGF-β1-treated human embryonic stem cells (hESCs). Moreover, lncRNA TUG1-silenced alleviated TGF-β1-induced the proliferation and migration abilities of hESCs and enhanced inflammatory cytokines secretion in vitro. In vivo experiments showed that inhibition of lncRNA TUG1 promoted endometrium regeneration in IUA rats through downregulating inflammatory response and epithelial-to-mesenchymal transition (EMT) process. Mechanistically, lncRNA TUG1 suppression attenuated EMT process and inflammation through competitively binding miR-590-5p to downregulate Fasl expression. Collectively, our findings provide vital theoretical evidence for explaining the mechanisms of the lncRNA TUG1/miR-590-5p/Fasl axis in the progression of IUA, and may provide a new biomarker for the treatment of IUA patients. © 2020

基金：
Health Science and Technology Program of Yunnan Province (NO. 2014NS233, 2016NS193, 2017NS214).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
JCR分区：
出版当年[2019]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [a]Department of Obstetrics & Gynecology, The First People's Hospital of Yunnan Province, No. 157 Jinbi Road, Kunming, Yunnan
通讯作者：
推荐引用方式(GB/T 7714)：
Ai Y,Chen M,Liu J,et al.lncRNA TUG1 promotes endometrial fibrosis and inflammation by sponging miR-590-5p to regulate Fasl in intrauterine adhesions[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2020,86:doi:10.1016/j.intimp.2020.106703.
APA：
Ai, Y,Chen, M,Liu, J,Ren, L,Yan, X&Feng, Y.(2020).lncRNA TUG1 promotes endometrial fibrosis and inflammation by sponging miR-590-5p to regulate Fasl in intrauterine adhesions.INTERNATIONAL IMMUNOPHARMACOLOGY,86,
MLA：
Ai, Y,et al."lncRNA TUG1 promotes endometrial fibrosis and inflammation by sponging miR-590-5p to regulate Fasl in intrauterine adhesions".INTERNATIONAL IMMUNOPHARMACOLOGY 86.(2020)

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