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The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats

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收录情况： ◇ SCIE

作者：
Dafu Yu [a,c,d] * ; Heng Zhou[b,c] * ; Yuan Yang[a,c,e] ; Yong Jiang[d] ; TianchaoWang [d] ; Liang Lv [d] ; Qixin Zhou [c] ; Yuexiong Yang [c] ; Xuexian Dong[d] ; Jianfeng He [d] ; Xiaoyan Huang[f] ; Jijun Chen[f] ; Kunhua Wu [d] ; Lin Xu [a,b,c,*1] ; Rongrong Mao[c,*1] ;
机构： [a]School of Life Sciences, Yunnan University, Kunming, 650091, China [b]School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China [c]Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Science, And KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, And Laboratory of Learning and Memory, Kunming Institute of Zoology, Kunming, 650223, China [d]Department of Nuclear Medicine, First People's Hospital of Yunnan Province, And Key Laboratory of Medical Imaging, Medical Faculty, Kunming University of Science and Technology, Kunming, 650032, China [e]Physiological Department, Kunming Medical University, Kunming, 650500, China [f]State Key Laboratory of Phytochemistry and Plant Resources in Southwest China, And Kunming Institute of Botany, Chinese Academy of Science, Kunming, 650201, China
出处：
DOI： 10.1016/j.yhbeh.2015.01.003
ISSN：

关键词： Anxiety Brain-derived neurotrophic factor Depression Hyperthyroidism Hypothyroidism

摘要：
Thyroid hormone disorders have long been linked to depression, but the causal relationship between them remains controversial. To address this question, we established rat models of hypothyroidism using 131iodine (131I) and hyperthyroidism using levothyroxine (LT4). Serum free thyroxine (FT4) and triiodothyronine (FT3) significantly decreased in the hypothyroid of rats with single injections of 131I (5mCi/kg). These rats exhibited decreased depression-like behaviors in forced swimming test and sucrose preference tests, as well as decreased anxiety-like behaviors in an elevated plus maze. Diminished levels of brain serotonin (5-HT) and increased levels of hippocampal brain-derived neurotrophic factor (BDNF) were found in the hypothyroid rats compared to the control saline-vehicle administered rats. LT4 treatment reversed the decrease in thyroid hormones and depression-like behaviors. In contrast, hyperthyroidism induced by weekly injections of LT4 (15μg/kg) caused a greater than 10-fold increase in serum FT4 and FT3 levels. The hyperthyroid rats exhibited higher anxiety- and depression-like behaviors, higher brain 5-HT level, and lower hippocampal BDNF levels than the controls. Treatment with the antidepressant imipramine (15mg/kg) diminished serum FT4 levels as well as anxiety- and depression-like behaviors in the hyperthyroid rats but led to a further increase in brain 5-HT levels, compared with the controls or the hypothyroid rats. Together, our results suggest that hypothyroidism and hyperthyroidism have bidirectional effects on anxiety- and depression-like behaviors in rats, possibly by modulating hippocampal BDNF levels. © 2015 Elsevier Inc.

基金：
We thank Dr. Graham Thomas for polishing the English language of the manuscript. This work was supported by grants from the 973 Project ( 2013CB835103 ), NSFC-CIHR ( 81161120536 ), the Chinese Academy of Sciences ( XDB0202002 ), NSFC ( 31100786 , U1032605 and U1132602 ), NSFC ( 81171294 ), the Science and Technology Program of Yunnan Province ( 2013GA003 and 2010CD104 ), and the Natural Scientific Research fund ( #508 in 2011) of the Chinese Human Resources and Social Security Department.
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 2 区 医学
小类 | 2 区 行为科学 3 区 内分泌学与代谢
最新[2023]版：
大类 | 3 区 医学
小类 | 2 区 行为科学 3 区 内分泌学与代谢
JCR分区：
出版当年[2014]版：
Q1 BEHAVIORAL SCIENCES Q1 ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q2 BEHAVIORAL SCIENCES Q3 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者机构： [a]School of Life Sciences, Yunnan University, Kunming, 650091, China [c]Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Science, And KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, And Laboratory of Learning and Memory, Kunming Institute of Zoology, Kunming, 650223, China [d]Department of Nuclear Medicine, First People's Hospital of Yunnan Province, And Key Laboratory of Medical Imaging, Medical Faculty, Kunming University of Science and Technology, Kunming, 650032, China
共同第一作者：
通讯作者：
通讯机构： [a]School of Life Sciences, Yunnan University, Kunming, 650091, China [b]School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China [c]Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Science, And KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, And Laboratory of Learning and Memory, Kunming Institute of Zoology, Kunming, 650223, China [*1]Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223 Yunnan, China
推荐引用方式(GB/T 7714)：
Dafu Yu,Heng Zhou,Yuan Yang,et al.The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats[J].Hormones and behavior.2015,69:106-115.doi:10.1016/j.yhbeh.2015.01.003.
APA：
Dafu Yu,Heng Zhou,Yuan Yang,Yong Jiang,TianchaoWang...&Rongrong Mao.(2015).The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats.Hormones and behavior,69,
MLA：
Dafu Yu,et al."The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats".Hormones and behavior 69.(2015):106-115

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