机构：[a]Medical Faculty of Kunming University of Science and Technology, Kunming, Yunnan, 650500, China[b]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, ChineseAcademy of Sciences, Kunming, 650223, China[c]Institute of Translation Medicine, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China深圳市第二人民医院深圳医学信息中心[d]KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming,650223, China[e]Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, China
The dysfunction of E3 ubiquitin ligases is important in the pathogenesis of many human diseases, as they play important roles in multiple cellular processes. In this review, we evaluated the structures, functions and clinical significance of two RING-type E3 ubiquitin ligases from the same subfamily, ring-finger protein 126 (RNF126) and breast cancer associated gene 2 (BCA2). Interestingly, the expression of RNF126 and BCA2 are regulated by multiple signaling pathways, including EGFR, ERK, AKT, and NF-kappa B. RNF126 and BCA2 appear to be functional mediators for not only DNA damage repair but also cancer development. Due to their significant functions in cell proliferation and DNA damage repair, RNF126 and BCA2 may be two potential diagnostic biomarkers and therapeutic targets for cancers.
基金：
National Key R&D Program of China [2018YFC2000400]; National Natural Science Foundation of China [81830087, 81773149, U1602221, 31771516]; Science and Technology Department of Yunnan Province [2019HC005, 2018FB134]; Shenzhen Municipal Government of China [KQTD20170810160226082]
第一作者机构：[a]Medical Faculty of Kunming University of Science and Technology, Kunming, Yunnan, 650500, China[b]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, ChineseAcademy of Sciences, Kunming, 650223, China
通讯作者：
通讯机构：[b]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, ChineseAcademy of Sciences, Kunming, 650223, China[c]Institute of Translation Medicine, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China[d]KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming,650223, China[e]Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, China[*1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
推荐引用方式(GB/T 7714)：
Rou Zhang,Wenjin Liu,Jian Sun,et al.Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy[J].PHARMACOLOGICAL RESEARCH.2020,155:doi:10.1016/j.phrs.2020.104748.
APA：
Rou Zhang,Wenjin Liu,Jian Sun,Yanjie Kong&Ceshi Chen.(2020).Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy.PHARMACOLOGICAL RESEARCH,155,
MLA：
Rou Zhang,et al."Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy".PHARMACOLOGICAL RESEARCH 155.(2020)
：
医学