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A novel Schiff base cobalt(III) complex induces a synergistic effect on cervical cancer cells by arresting early apoptosis stage

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收录情况： ◇ SCIE

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机构： [1]School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China [2]Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China [3]Biobank, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China

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关键词： Schiff base Co(III) complex Cell cycle DNA damage ER stess c-Myc and KLF5

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A new schiff base cobalt(III) complex [N,N '-bis(2 '-hydroxyphenylacetone)-o-ethanediamine] cobalt(III) (M3) has been synthesized and characterized by single X-ray crystallography. The cytotoxicity of complex M3 was evaluated against HeLa, LoVo, A549, A549/cis cancer cell lines, and the normal cell lines LO2 by MTT assays. The IC50 is in the range of 6.27-22.68 mu M, which is somewhat lower than cisplatin on the basis of platinum molar concentration. Furthermore, anticancer mechanistic studies showed that the complex M3 inhibited cell proliferation by blocking DNA synthesis and then acted on nuclear division of HeLa cells over time. Moreover, western blot analysis indicated M3 dramatically decreased the target protein c-Myc and KLF5 expression levels, and activated many signaling pathways including ER stress, apoptosis, cell cycle and DNA damage in HeLa. M3 did not affect proteasomal activity.

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出版当年[2021]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 4 区生化与分子生物学

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出版当年[2020]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 4.1 最新[2023版] 3.7 最新五年平均 2.949 出版当年[2020版] 2.978 出版当年五年平均 2.479 出版前一年[2019版] 3.378 出版后一年[2021版]

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第一作者机构： [1]School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China

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