机构：[1]Department of General Surgery, Xi'an Children’s Hospital, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, China[2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China[3]Department of Clinical Laboratory, Biobank, Harbin Medical University Cancer Hospital, Harbin, China[4]Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, China中国医科大学附属盛京医院中国医科大学盛京医院[5]Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[6]Department of Pediatric Surgery, Hunan Children’s Hospital, Changsha, China[7]Department of Pediatric Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China[8]Department of Hematology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China[9]Department of Pathology, Children Hospital and Women Health Center of Shanxi, Taiyuan, China[10]Kunming Key Laboratory of Children Infection and Immunity, Yunnan Key Laboratory of Children’s Major Disease Research, Yunnan Institute of Pediatrics Research, Yunnan Medical Center for Pediatric Diseases, Kunming Children’s Hospital, Kunming, China
Neuroblastoma ranks as the most commonly seen and deadly solid tumour in infancy. The aberrant activity of m(6)A-RNA methyltransferase METTL3 is involved in human cancers. Therefore, functional genetic variants in theMETTL3gene may contribute to neuroblastoma risk. In the current nine-centre case-control study, we aimed to analyse the association between theMETTL3gene single nucleotide polymorphisms (SNPs) and neuroblastoma susceptibility. We genotyped fourMETTL3gene SNPs (rs1061026 T>G, rs1061027 C>A, rs1139130 A>G, and rs1263801 G>C) in 968 neuroblastoma patients and 1814 controls in China. We found significant associations between these SNPs and neuroblastoma risk in neither single-locus nor combined analyses. Interestingly, in the stratified analysis, we observed a significant risk association with rs1061027 AA in subgroups of children <= 18 months of age (adjusted OR = 1.87, 95% CI = 1.03-3.41,P = .040) and females (adjusted OR = 1.86, 95% CI = 1.07-3.24,P = .028). Overall, we identified a significant association betweenMETTL3gene rs1061027 C>A polymorphism and neuroblastoma risk in children <= 18 months of age and females. Our findings provide novel insights into the genetic determinants of neuroblastoma.
基金：
Natural Science Foundation of Guangdong
Province, Grant/Award Number:
2019A1515010360; Guangdong Provincial
Key Laboratory of Research in Structural
Birth Defect Disease, Grant/Award Number:
2019B030301004
第一作者机构：[1]Department of General Surgery, Xi'an Children’s Hospital, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, China[*2]Department of General Surgery, Xi'an Children's Hospital, Xi'an Jiaotong University Affiliated Children's Hospital, 69 Xiju Court Lane, Xi'an 710003, Shaanxi, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of General Surgery, Xi'an Children’s Hospital, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, China[2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China[*1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou 510623, Guangdong, China.[*2]Department of General Surgery, Xi'an Children's Hospital, Xi'an Jiaotong University Affiliated Children's Hospital, 69 Xiju Court Lane, Xi'an 710003, Shaanxi, China
推荐引用方式(GB/T 7714)：
Bian Jun,Zhuo Zhenjian,Zhu Jinhong,et al.Association betweenMETTL3gene polymorphisms and neuroblastoma susceptibility: A nine-centre case-control study[J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2020,24(16):9280-9286.doi:10.1111/jcmm.15576.
APA：
Bian, Jun,Zhuo, Zhenjian,Zhu, Jinhong,Yang, Zhonghua,Jiao, Zhang...&Liu, Yanfei.(2020).Association betweenMETTL3gene polymorphisms and neuroblastoma susceptibility: A nine-centre case-control study.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,24,(16)
MLA：
Bian, Jun,et al."Association betweenMETTL3gene polymorphisms and neuroblastoma susceptibility: A nine-centre case-control study".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 24..16(2020):9280-9286
医学