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METTL14 Gene Polymorphisms Confer Neuroblastoma Susceptibility: An Eight-Center Case-Control Study.

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收录情况： ◇ SCIE

作者：
Zhuo Zhenjian[1] * ; Lu Hongting[2] * ; Zhu Jinhong[1,3] * ; Hua Rui-Xi[1] ; Li Yong[4] ; Yang Zhonghua[5] ; Zhang Jiao[6] ; Cheng Jiwen[7] ; Zhou Haixia[8] ; Li Suhong[9] ; Li Li[10] ; Xia Huimin[1,*1] ; He Jing[1,*1] ;
机构： [1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China [2]Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China [3]Department of Clinical Laboratory, Biobank, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, China [4]Department of Pediatric Surgery, Hunan Children’s Hospital, Changsha 410004, Hunan, China [5]Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China [6]Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China [7]Department of Pediatric Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China [8]Department of Hematology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China [9]Department of Pathology, Children Hospital and Women Health Center of Shanxi, Taiyuan 030013, Shannxi, China [10]Kunming Key Laboratory of Children Infection and Immunity, Yunnan Key Laboratory of Children’s Major Disease Research, Yunnan Institute of Pediatrics Research, Yunnan Medical Center for Pediatric Diseases, Kunming Children’s Hospital, Kunming 650228, Yunnan, China
出处：
DOI： 10.1016/j.omtn.2020.08.009
ISSN：

关键词： case-control study m6A METTL14 neuroblastoma polymorphism

摘要：
Neuroblastoma is the primary cause of cancer death in childhood. METTL14 is tightly linked to cancer. However, whether single-nucleotide polymorphisms (SNPs) in the METTL14 gene could predispose to neuroblastoma susceptibility lacks evidence. With an epidemiology case-control study, associations between METTL14 gene SNPs and overall risk for neuroblastoma were estimated in 898 cases and 1,734 controls. Following that, stratified analysis was performed. Among the five analyzed SNPs, rs298982 G>A and rs62328061 A>G exhibited a significant association with decreased susceptibility to neuroblastoma, whereas the associations with increased neuroblastoma susceptibility were observed for rs9884978 G>A and rs4834698 T>C. Moreover, subjects carrying two to five risk genotypes were more inclined to develop neuroblastoma than those with zero to one risk genotypes. The stratified analysis further demonstrated the protective effect of rs298982 G>A and rs62328061 A>G, as well as the predisposing effect of rs4834698 T>C and two to five risk genotypes, in certain subgroups. Haplotype analysis was performed. Moreover, false-positive report probability analysis validated the reliability of the significant results. The expression quantitative trait locus analysis revealed that rs298982 is correlated with the expression levels of its surrounding genes. Our results suggest that some SNPs in the METTL14 gene are associated with predisposition to neuroblastoma. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
Natural Science Foundation of Guangdong Province (grant 2019A1515010360), Pearl River S&T Nova Program of Guangzhou (grant 201710010086), and Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease (grant 2019B030301004).
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验
JCR分区：
出版当年[2019]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China [*1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou 510623, Guangdong, China
推荐引用方式(GB/T 7714)：
Zhuo Zhenjian,Lu Hongting,Zhu Jinhong,et al.METTL14 Gene Polymorphisms Confer Neuroblastoma Susceptibility: An Eight-Center Case-Control Study.[J].MOLECULAR THERAPY-NUCLEIC ACIDS.2020,22:17-26.doi:10.1016/j.omtn.2020.08.009.
APA：
Zhuo Zhenjian,Lu Hongting,Zhu Jinhong,Hua Rui-Xi,Li Yong...&He Jing.(2020).METTL14 Gene Polymorphisms Confer Neuroblastoma Susceptibility: An Eight-Center Case-Control Study..MOLECULAR THERAPY-NUCLEIC ACIDS,22,
MLA：
Zhuo Zhenjian,et al."METTL14 Gene Polymorphisms Confer Neuroblastoma Susceptibility: An Eight-Center Case-Control Study.".MOLECULAR THERAPY-NUCLEIC ACIDS 22.(2020):17-26

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