机构：[1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural BirthDefect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China[2]Department of PediatricSurgery, The Affiliated Hospital of Qingdao University, Qingdao, China[3]Department of Pediatric Surgery, Shengjing Hospital of China MedicalUniversity, Shenyang, China中国医科大学附属盛京医院中国医科大学盛京医院[4]Kunming Key Laboratory of Children Infection and Immunity, Yunnan Key Laboratory of Children’s Major DiseaseResearch, Yunnan Institute of Pediatrics Research, Yunnan Medical Center for Pediatric Diseases, Kunming Children’s Hospital, Kunming, China[5]Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[6]Department of Pediatric Surgery, theSecond Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China[7]Department of Pediatric Surgery, Hunan Children’s Hospital, Changsha,China[8]Department of Pathology, Children Hospital and Women Health Center of Shanxi, Taiyuan, China[9]Department of Hematology, TheSecond Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
Previous studies have revealed that WTAP is related to multiple types of cancer. Recently, WTAP has been reported as an independent prognostic factor in patients with neuroblastoma.
To explore the association between three WTAP polymorphisms (rs9457712 G>A, rs1853259 A>G and rs7766006 G>T) and neuroblastoma susceptibility in Chinese populations, we performed this case-control study including 898 neuroblastoma cases and 1,734 controls. We genotyped these potentially functional single nucleotide polymorphisms (SNPs) by TaqMan assays. The odds ratios (ORs) and 95% confidence intervals (CIs) by logistic regression models were used to assess the relationship between WTAP SNPs and the risk of neuroblastoma.
No significant associations were observed in the overall analysis between any of the three WTAP polymorphisms and the risk of neuroblastoma. However, in the age ≤18 months subgroup, we found that the rs1853259 AG/GG genotype exerted protective effects against neuroblastoma (adjusted OR =0.77, 95% CI: 0.59-0.998, P=0.048), whereas the presence of 1-2 combined risk genotypes significantly increased the risk of neuroblastoma (adjusted OR =1.32, 95% CI: 1.02-1.71, P=0.036).
WTAP gene polymorphisms only have a weak impact on the risk of neuroblastoma in the Chinese children. Further case-control studies, preferable on larger sample sizes, are needed to validate our results.
2021 Translational Pediatrics. All rights reserved.
基金：
Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2019A1515010360]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81560262, 81960294]; Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease [2019B030301004]
第一作者机构：[1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural BirthDefect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural BirthDefect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China[*1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou 510623, China
推荐引用方式(GB/T 7714)：
Tang Jue,Lu Hongting,Yang Zhonghua,et al.Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children.[J].TRANSLATIONAL PEDIATRICS.2021,10(1):146-+.doi:10.21037/tp-20-168.
APA：
Tang Jue,Lu Hongting,Yang Zhonghua,Li Le,Li Li...&Liu Wei.(2021).Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children..TRANSLATIONAL PEDIATRICS,10,(1)
MLA：
Tang Jue,et al."Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children.".TRANSLATIONAL PEDIATRICS 10..1(2021):146-+
