机构：[1]School of Stomatology and Medicine, Foshan University Foshan 528000, Guangdong, China.[2]Portola High School 1001 Cadence, Irvine 92618, CA, USA.[3]Affiliated Cancer Hospital and Institute of Guangzhou Medical University Guangzhou 510095, Guangdong, China.[4]Research Service, Memphis VA Medical Center Memphis 38104, TN, USA.[5]Department of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center Columbus 43210, USA.[6]Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences Kunming 650223, Yunnan, China.[7]Kunming College of Life Science, University of Chinese Academy of Sciences Kunming 650204, Yunnan, China.
Burkitt's lymphoma (BURK), diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) are three main types of B-cell lymphomas. This study aimed to compare the differences of affected biological functions and pathways, as well as to explore the possible regulatory mechanisms and the potential therapeutic targets in BURK, DLBCL and MCL. We performed an integrated analysis of 10 lymphoma datasets including 352 BURK patients, 880 DLBCL patients, 216 MCL patients, and 33 controls. Our results showed that signaling pathways, amino acid metabolism and several lipid metabolism pathways varies considerably among these three types of lymphoma. Furthermore, we identified several key transcription factors (TFs) and their target genes that may promote these diseases by influencing multiple carcinogenic pathways. Among these TFs, we reported first that E2F8 displayed the most significant effects in BURK and MCL. Our results demonstrate that over-expression of E2F8 activates target genes that may promote cell cycle, mitosis, immune and other cancer related functions in BURK and MCL. Therefore, we suggest that E2F8 could be used as a biomarker and potential therapeutic target for BURK and MCL. These findings would be helpful in the study of pathogenesis, and drug discovery and also in the prognosis of B cell lymphomas.
基金：
National Na-tural Science Foundation of China (No. 815-70376, No. 81870307, No. 81570202), the Scientific Research Startup Fund of Foshan University (Grant No. CGg07025), the Featured Project of Innovation Enhancing College of Guangdong Province (No. 2015KTSCX154), the University Special Innovative Research Pro-gram of Department of Education of Guang-dong Province (No. 2017KTSCX189) and Fo-shan Science and Technology Innovation Pro-ject (No. 2015AG10010).
第一作者机构：[1]School of Stomatology and Medicine, Foshan University Foshan 528000, Guangdong, China.
共同第一作者：
通讯作者：
通讯机构：[1]School of Stomatology and Medicine, Foshan University Foshan 528000, Guangdong, China.[5]Department of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center Columbus 43210, USA.[6]Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences Kunming 650223, Yunnan, China.[7]Kunming College of Life Science, University of Chinese Academy of Sciences Kunming 650204, Yunnan, China.[*1]School of Stomatology and Medicine, Foshan Univer-sity, Foshan 528000, Guangdong, China[*2]Department of Internal Medicine, Ohio State Uni-versity College of Medicine and Wexner Medical Center, Columbus 43210, USA[*3]Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
推荐引用方式(GB/T 7714)：
Yang An-Ping,Liu Leyna G,Chen Min-Min,et al.Integrated analysis of 10 lymphoma datasets identifies E2F8 as a key regulator in Burkitt's lymphoma and mantle cell lymphoma[J].AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH.2019,11(7):4382-+.
APA：
Yang An-Ping,Liu Leyna G,Chen Min-Min,Liu Fang,You Hua...&Li Wen-Xing.(2019).Integrated analysis of 10 lymphoma datasets identifies E2F8 as a key regulator in Burkitt's lymphoma and mantle cell lymphoma.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,11,(7)
MLA：
Yang An-Ping,et al."Integrated analysis of 10 lymphoma datasets identifies E2F8 as a key regulator in Burkitt's lymphoma and mantle cell lymphoma".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 11..7(2019):4382-+
