机构：[1]Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China[2]Department of Epidemiology and Bio-Statistics (YW), Peking Union Medical College, Institute of Basic Medical Sciences, China Academy of Medical Sciences, Beijing, China[3]Department of Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University, Xi’an, China[4]Department of Rheumatology, Kunming Medical University First Affiliated Hospital, Kunming, China昆明医科大学附属第一医院[5]Department of Rheumatology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, China[6]Department of Rheumatology, The People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, China[7]Department of Rheumatology, Guangxi Medical University First Affiliated Hospital, Nanning, China[8]Department of Rheumatology, Nanchang University Second Affiliated Hospital, Nanchang, China[9]Department of Rheumatology, First People’s Hospital of Yunnan, Kunming, China[10]Department of Rheumatology, Sichuan Provincial People’s Hospital, Chengdu, China四川省人民医院[11]Department of Rheumatology, Xinxiang Central Hospital, Xinxiang, China
Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China. Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA database was performed. Demographic and clinical data were compared in terms of the HLA-B27 status. Univariate and multivariate analyses were performed to identify variables related to HLA-B27 presence. Results: We enrolled 4,131 patients in this study; of those, 36,95 (89.4%) were HLA-B27 positive. In the multivariate analysis, male gender (p < 0.001), younger age (p < 0.001), a disease duration of more than 3 years (p < 0.001), a family history of SpA (p < 0.001), uveitis (p < 0.001), ASDAS-CRP (p < 0.001), and biologic treatment (p < 0.001) were the main variables that were independently related to HLA-B27 presence, whereas a diagnosis delay time >36 months (p < 0.001) and psoriasis (p < 0.001) were independently related to HLA-B27 absence. Conclusion: In Chinese axial SpA patients, presence of HLA-B27 is associated with the male sex, younger age, longer disease duration, greater family aggregation, and higher frequency of uveitis; absence of HLA-B27 is associated with longer diagnosis delay time and higher frequency of psoriasis.
基金：
CAMS Innovation Fund for Medical Sciences [2019-I2M-2-008]
第一作者机构：[1]Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Shangzhu,Wang Yanhong,Peng Linyi,et al.Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients[J].FRONTIERS IN MEDICINE.2020,7:doi:10.3389/fmed.2020.609562.
APA：
Zhang, Shangzhu,Wang, Yanhong,Peng, Linyi,Su, Jinmei,Zeng, Xiaofeng...&Fan, Wenqiang.(2020).Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients.FRONTIERS IN MEDICINE,7,
MLA：
Zhang, Shangzhu,et al."Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients".FRONTIERS IN MEDICINE 7.(2020)
