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SH3BGRL2 functions as a crucial tumor suppressor in glioblastoma tumorigenesis.

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China. [2]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China. [3]Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, 266071, China. [4]Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.

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关键词： Glioma GSCs SH3BGRL2 Tumor suppressor Biomarker

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Glioblastoma is the most common and severe primary intrinsic tumor of the central nervous system. Glioblastoma harbors glioma stem cells (GSCs) as it not only possesses self-renewal and differentiation properties but also accounts for significant chemotherapy resistance and recurrence. Thus, targeting GSCs may be essential in overcoming the resistance and recurrence thereby improving GBM treatment. However, the underlying mechanism to sustain GSCs remains largely unknown. Here, we report that SH3 domain binding glutamate-rich protein like 2 (SH3BGRL2) is weakly expressed in glioblastoma multiforme (GBM) and isocitrate dehydrogenase1 (IDH1) wildtype GBM and correlated with glioma patients' poor prognosis. Moreover, ectopic expression of SH3BGRL2 significantly inhibited GBM cell growth, migration, and GSCs self-renewal in vitro as well as tumor growth in vivo. Additionally, we found that SH3BGRL2 suppressed SOX2 and CD133 expression, which are key regulators involved in GSCs self-renewal. Collectively, our findings shed additional light on SH3BGRL2 has potential to serve as a biomarker and a potent therapeutic target for patients with glioma. Copyright © 2021 Elsevier Inc. All rights reserved.

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出版当年[2021]版：

大类 | 3 区生物

小类 | 3 区生物物理 4 区生化与分子生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

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出版当年[2020]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 3.575 出版当年[2020版] 3.381 出版当年五年平均 2.985 出版前一年[2019版] 3.322 出版后一年[2021版]

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第一作者机构： [1]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.

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