机构：[1]Department of Tumor 2 Families, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei 445000[2]Department of Thoracic Surgery Ward II, Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650100[3]Department of Clinical Medicine, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei 445000[4]Department of Neurosurgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510400, P.R. China深圳市中医院深圳医学信息中心
Glioma is one of the most common types of malignant cancer and the significance of microRNAs (miRNAs) in cancer therapy has been demonstrated. In the current study, miR-490-3p expression was significantly downregulated in glioma tissue and cell lines. Overexpression of miR-490-3p inhibited glioma cell proliferation and migration in vitro. In addition, the high-mobility group AT-hook 2 (HMGA2) was identified as a candidate target gene of miR-490-3p. The current study demonstrated that miR-490-3p mimic could inhibit HMGA2 protein expression in glioma cells. In addition, correlation analysis demonstrated that miR-490-3p and HMGA2 expression was inversely correlated in glioma tissues. Furthermore, the inhibitory effect of miR-490-3p mimic on cell proliferation and migration was partially reversed by the overexpression of HMGA2. Taken together, these results suggest that miR-490-3p may have a tumor suppressive role in glioma and therefore miR-490-3p may be a new target for the treatment of glioma.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Tumor 2 Families, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei 445000
通讯作者：
通讯机构：[4]Department of Neurosurgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510400, P.R. China[*1]Department of Neurosurgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 18 Jichang Road, Baiyun, Guangzhou, Guangdong 510400, P.R. China
推荐引用方式(GB/T 7714)：
Zhang Fang,Wu Anhao,Wang Yinhui,et al.miR-490-3p functions as a tumor suppressor in glioma by inhibiting high-mobility group AT-hook 2 expression.[J].Experimental and therapeutic medicine.2019,18(1):664-670.doi:10.3892/etm.2019.7606.
APA：
Zhang Fang,Wu Anhao,Wang Yinhui&Liu Jianmin.(2019).miR-490-3p functions as a tumor suppressor in glioma by inhibiting high-mobility group AT-hook 2 expression..Experimental and therapeutic medicine,18,(1)
MLA：
Zhang Fang,et al."miR-490-3p functions as a tumor suppressor in glioma by inhibiting high-mobility group AT-hook 2 expression.".Experimental and therapeutic medicine 18..1(2019):664-670
