机构：[1]Institute for Cardiovascular Science & Department of Cardiovascular Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.[2]Department of Cardiac Surgery, Fuwai Hospital, Beijing, People's Republic of China.[3]Fuwai Yunnan Cardiovascular Hospital, Kunming, Yunnan, People's Republic of China.[4]University of Texas, Houston, TX, USA.[5]Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China
Muscle atrophy in aging is characterized by progressive loss of muscle mass and function. Muscle mass is determined by the balance of synthesis and degradation of protein, which are regulated by several signaling pathways such as ubiquitin-proteasome system, autophagy-lysosome systems, oxidative stress, proinflammatory cytokines, hormones, and so on. Sufficient nutrition can enhance protein synthesis, while exercise can improve the quality of life in the elderly. This chapter will discuss the epidemiology, pathogenesis, as well as the current treatment for aging-induced muscular atrophy.
基金：
Jiangsu Province Key Scientific and
Technological Project (BE2016669), a Suzhou Science and Technology Project (SS201665),
Jiangsu Province Peak of Talent in Six Industries (BU24600117), Jiangsu Province Key Discipline/
Laboratory of Medicine (XK201118), and the Priority Academic Program Development of Jiangsu
Higher Education Institutions (PAPD).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|3 区生物学4 区医学：研究与实验
最新[2023]版：
无
第一作者：
第一作者机构：[1]Institute for Cardiovascular Science & Department of Cardiovascular Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Yu,Pan Xiangbin,Sun Yi,et al.The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging.[J].Advances in experimental medicine and biology.2018,1088:347-368.doi:10.1007/978-981-13-1435-3_16.
APA：
Zhang Yu,Pan Xiangbin,Sun Yi,Geng Yong-Jian,Yu Xi-Yong&Li Yangxin.(2018).The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging..Advances in experimental medicine and biology,1088,
MLA：
Zhang Yu,et al."The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging.".Advances in experimental medicine and biology 1088.(2018):347-368
