Secondary hemophagocytic lymphohistiocytosis (sHLH) is an excessive inflammatory response syndrome caused by immune abnormalities. Up to date, the risk factors for cytokines causing early death in sHLH patients have not been elucidated. Our study reviewed the cytokine expression levels in peripheral blood of 50 sHLH patients. Through Cox proportional hazard model analysis, we found that IL-17F >= 2.835 pg/mL (HR = 5.922, 95% CI = 1.793-19.558, P = 0.004) was an independent death risk factor in sHLH patients, and it was also 30 days (Cutoff value = 2.890 pg/mL, HR = 16.568, 95% CI = 1.917-143.195, P = 0.011), 60 days (Cutoff-value = 2.890 pg/mL, HR = 7.559, 95% CI = 1.449-39.423, P = 0.016), 90 day death risk factor (Cutoff-value = 2.835 pg/mL, HR = 7.649, 95% CI = 1.965-29.778, P = 0.003); IL-10 >= 16.730 pg/mL (HR = 4.821, 95% CI = 1.151-20.116, P = 0.031) is not only a death risk factor within 90 days, but also within 10 days (Cutoff-value = 944.350 pg/mL, HR = 13.321, 95% CI = 1.123-158.03, P = 0.027); and IL-5 >= 2.495 pg/mL (HR = 15.687, 95% CI = 1.377-178.645, P = 0.04) was also a death risk factor within 10 days. Besides, IL-17F, IL-10, IL-5, and the previously reported common risk factors Age, platelets, activated partial thromboplastin time, triglyceride, and lactate dehydrogenase were analyzed together. It was found that the patient age >= 56 years-old is was an important risk factor for death within 30 days, IL-17 >= 2.89 pg/mL and IL-10 >= 16.73 pg/mL are important risk factors for patient death. In summary, our data indicate that age, IL-10 and IL-17F are important risk factors for early death in sHLH patients.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82070173, 81700164, 82060810]; Yunnan Applied Basic Research Projects Foundation [2018FB112]; Medical Reserve Talents Cultivation Project of Yunnan Province [H2017012]; Science and Technology Department of Yunnan Province-Kunming Medical University Applied Basic Research Joint Special Fund Young Doctor Project [2018-FE001(-156)]; Doctor Research Fund of Yunnan First People's Hospital [KHBS-2020007]; Open Project of Yunnan Blood Clinical Medical Center [2019LCZXKF-XY02, 2020-LCZXKF-XY14, 2019LCZXKF-XY11]
第一作者机构：[1]First Peoples Hosp Yunnan Prov, Dept Hematol, 157 Jinbi Rd, Kunming 650032, Yunnan, Peoples R China[2]Yunnan Blood Dis Clin Med Ctr, Kunming, Yunnan, Peoples R China[3]Yunnan Blood Dis Hosp, Kunming, Yunnan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]First Peoples Hosp Yunnan Prov, Dept Hematol, 157 Jinbi Rd, Kunming 650032, Yunnan, Peoples R China[2]Yunnan Blood Dis Clin Med Ctr, Kunming, Yunnan, Peoples R China[3]Yunnan Blood Dis Hosp, Kunming, Yunnan, Peoples R China[4]Kunming Univ Sci & Technol, Kunming, Yunnan, Peoples R China[*1]Department of Hematology, The First People’s Hospital of Yunnan Province, 157 Jinbi Road, Kunming 650032, China
推荐引用方式(GB/T 7714)：
Li Zengzheng,Liu Jianqiong,Man Yan,et al.Original Article Analysis of cytokine risk factors in the early death of patients with secondary phagocytic lymphocytic histiocytosis[J].AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH.2021,13(4):2388-2398.
APA：
Li, Zengzheng,Liu, Jianqiong,Man, Yan,Liu, Fusheng,Gao, Lili...&Yang, Tonghua.(2021).Original Article Analysis of cytokine risk factors in the early death of patients with secondary phagocytic lymphocytic histiocytosis.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,13,(4)
MLA：
Li, Zengzheng,et al."Original Article Analysis of cytokine risk factors in the early death of patients with secondary phagocytic lymphocytic histiocytosis".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 13..4(2021):2388-2398
