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Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial.

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wu Lingling[1,*1] * ; Zhao Haiyan[2] * ; Zhang Zijing[1] ; Huang Minli[1] ; Wu Shuzhen[1] ; Fang Changping[1] ; Wang Ren[3] ; Li Shangrong[3] ; Yi Wei[4] ; Zhou Andong[5] ;
机构： [1]Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China [2]Department of Gynecology, the First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650034, Yunnan, China [3]Department of Anesthesiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China [4]Acupuncture-Moxibustion and Rehabilitation Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China [5]Department of Clinical Medicine, the Second Clinical Medical School of Guangdong Medical University, Dongguan 523808, Guangdong, China
出处：
DOI： 10.1016/j.clim.2022.108935
ISSN：

关键词： Labor analgesia Combined spinal-epidural anesthesia Acupoint injection Interleukin-1β Interleukin-10 Labor outcome

摘要：
This study aimed to investigate the effects of combined spinal-epidural anesthesia (CSEA) with acupoint injection (AI) on the maternal-fetal expression of interleukin-1β (IL-1β), interleukin-10 (IL-10), analgesia effect, and labor outcomes.A total of 360 healthy primiparas were randomized into the CSEA+AI group, the CSEA group, the AI group, and the control group (n = 90, each group) according to the labor analgesia methods.Compared to the CSEA group, the CSEA+AI group had significantly lower visual analog scale (VAS) scores, adverse events, dose of ropivacaine/sufentanil, and shorter labor durations. The IL-1β/IL-10 ratio in maternal peripheral blood and umbilical cord blood was reduced in the CSEA+AI group compared with the CSEA group.The combination of CSEA and AI can reduce the ratio of IL-1β/ IL-10 in maternal peripheral blood and umbilical cord blood, which can effectively relieve labor pain.Copyright © 2022. Published by Elsevier Inc.

基金：
Guangdong Science and Technology Department [Grant no.2016A020226051].
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
JCR分区：
出版当年[2021]版：
Q1 IMMUNOLOGY
最新[2023]版：
Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China [*1]Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou 510630, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China [*1]Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou 510630, Guangdong, China
推荐引用方式(GB/T 7714)：
Wu Lingling,Zhao Haiyan,Zhang Zijing,et al.Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial.[J].CLINICAL IMMUNOLOGY.2022,236:doi:10.1016/j.clim.2022.108935.
APA：
Wu Lingling,Zhao Haiyan,Zhang Zijing,Huang Minli,Wu Shuzhen...&Zhou Andong.(2022).Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial..CLINICAL IMMUNOLOGY,236,
MLA：
Wu Lingling,et al."Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial.".CLINICAL IMMUNOLOGY 236.(2022)

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