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Production of human cardiomyocytes based on a scalable stem cell culture platform

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机构： [1]Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, Yunnan, China [2]The First Peoples’ Hospital of Yunnan Province, No. 157, Jinbi Road, Kunming 650032, Yunnan, China [3]Key Laboratory of Cardiovascular Disease of Yunnan Province, Renmin East Road, Kunming 650051, Yunnan, China

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关键词： Cardiomyocytes Cardiovascular diseases Cell culture techniques Cell differentiation Induced pluripotent stem cells

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Cardiovascular diseases are serious and have become the main cause of death worldwide. Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) have been widely used in cardiovascular disease modeling, heart development research, drug screening and potential cell therapy. Efficient production of CMs from hiPSCs is crucial for its’ basic research and clinical translation. The three-dimensional (3D) suspension culture system is preferred in CMs culture, as it can achieve large-scale production and obtain more mature phenotype, but a robust stem cell culture platform remains unsolved. We previously established a scalable PSC culture platform (termed AIC) that supports PSC passaging at the single-cell level under 3D suspension conditions. However, the efficiency of hiPSCs derived from the AIC system directed differentiation into CMs remains unclear. The research aims to explore the differentiation efficiency of hiPSCs derived from the AIC system. © 2021 by American Scientific Publishers.

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大类 | 4 区材料科学

小类 | 4 区材料科学：综合 4 区纳米科技

影响因子： 0 最新[2023版] 0 最新五年平均 0 出版当年[2020版] 0 出版当年五年平均 1.65 出版前一年[2019版] 1.111 出版后一年[2021版]

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第一作者机构： [1]Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, Yunnan, China

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