机构：[1]Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, People’s Republic of China昆明医科大学附属第一医院[2]Innovation Class & Second Class, 2017 Clinical Medicine, Kunming Medical University, Kunming, People’s Republic of China[3]School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, People’s Republic of China
Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases. Methods: A review was conducted through an electronic search of PubMed and Medline databases. Keywords included Sestrin2, ROS, hypoxia, and hypoxia-related disease. Articles from 2008 to 2021 were mostly included and older ones were not excluded. Results: Sestrin2 is upregulated under various stress conditions, especially hypoxia. Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway. In addition, Sestrin2 is involved in various hypoxia-related diseases, such as cerebral hypoxic disease, myocardial hypoxic disease, hypoxia-related respiratory disease, and diabetes. Discussion: Sestrin2 is involved in various hypoxia-related diseases and maybe a therapeutic target. Furthermore, most studies focus on cerebral and myocardial ischemia reperfusion. More researches on hypoxia-related respiratory diseases, kidney injury, and diabetes are needed in future.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81560589, 30960450, 81173110, 81402991]; Yunnan Provincial Science and Technology Department [2019FE001 (-058), 202001AY070001-044]; Yunnan Provincial Department of Education [2018JS161]
第一作者机构：[1]Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, People’s Republic of China[2]Innovation Class & Second Class, 2017 Clinical Medicine, Kunming Medical University, Kunming, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, People’s Republic of China[3]School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, People’s Republic of China
推荐引用方式(GB/T 7714)：
Che Xiaojing,Chai Jiagui,Fang Yan,et al.Sestrin2 in hypoxia and hypoxia-related diseases[J].REDOX REPORT.2021,26(1):111-116.doi:10.1080/13510002.2021.1948774.
APA：
Che, Xiaojing,Chai, Jiagui,Fang, Yan,Zhang, Xifeng,Zu, Anju...&Yang, Weimin.(2021).Sestrin2 in hypoxia and hypoxia-related diseases.REDOX REPORT,26,(1)
MLA：
Che, Xiaojing,et al."Sestrin2 in hypoxia and hypoxia-related diseases".REDOX REPORT 26..1(2021):111-116
