机构：[1]Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.[2]Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.中山大学附属第二医院[3]Department of Endocrinology and Metabolism, People's Hospital of the Tibet Autonomous Region, Lhasa, Tibet, China.[4]Department of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, China.内科片内分泌科云南省第一人民医院[5]Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.[6]Department of Endocrinology, Qinghai Provincial People's Hospital, Xining, China.[7]Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China.[8]Department of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.四川大学华西医院[9]Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.[10]Department of Endocrinology, Health Science Affiliated Zhoupu Hosipital, Shanghai University of Medicine, Shanghai, China.[11]Department of Endocrinology, The First Hospital of An Hui Medical University, Hefei, China.[12]Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.[13]Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, China.[14]Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.大连医科大学附属第一医院[15]Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, China.[16]Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China.[17]Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.[18]Department of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University. Hohhot, China.[19]Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.[20]Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.[21]Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China.[22]Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.[23]Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.[24]Department of Endocrinology, Hainan General Hospital, Haikou, China.[25]Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.[26]Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.华中科技大学同济医学院附属协和医院[27]Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.[28]Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, China.[29]Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China.[30]Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.[31]Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension.Based on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Patients with a history of hypertension or thyroid disease were excluded. SCH was determined by manufacturer reference range. Overall hypertension and stage 1 and 2 hypertension were diagnosed according to the guidelines issued by the American College of Cardiology/American Heart Association in 2017.The prevalence of overall hypertension (48.7%), including stage 1 (28.9%) and 2 (19.8 %) hypertension, increased significantly in SCH patients compared with euthyroid subjects. With elevated serum thyroid stimulating hormone (TSH) level, the hypertension prevalence also increased significantly from the euthyroid to different SCH subgroups, which was more profound in females or subjects aged <65 years. The age- and sex-specific regression analysis further demonstrated the same trends in the general population and in the 1:1 propensity matched population. Similarly, several BP components (i.e., systolic, diastolic, and mean arterial BP) were positively associated with TSH elevation, and regression analysis also confirmed that all BP components were closely related with SCH in female subjects aged <65 years.The prevalence of hypertension increases for patients with SCH. SCH tends to be associated with hypertension and BP components in females younger than 65 years.
基金：
Research Fund for Public Welfare, National Health and Family Planning Commission of China (Grant No. 201402005) and the Clinical Research Fund of
Chinese Medical Association (Grant No. 15010010589).
第一作者机构：[1]Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.[*1]Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang 110001, China
推荐引用方式(GB/T 7714)：
Wang Xichang,Wang Haoyu,Yan Li,et al.The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65.[J].ENDOCRINOLOGY AND METABOLISM.2021,36(4):778-789.doi:10.3803/EnM.2021.1101.
APA：
Wang Xichang,Wang Haoyu,Yan Li,Yang Lihui,Xue Yuanming...&Shan Zhongyan.(2021).The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65..ENDOCRINOLOGY AND METABOLISM,36,(4)
MLA：
Wang Xichang,et al."The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65.".ENDOCRINOLOGY AND METABOLISM 36..4(2021):778-789
