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Genetic Polymorphisms in microRNA Genes Targeting PI3K/Akt Signal Pathway Modulate Cervical Cancer Susceptibility in a Chinese Population.

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收录情况： ◇ SCIE

作者：
Chen Kerong[1] * ; Yan Zhiling[2] * ; Dong Xudong[3] ; Liang Yan[4] ; Yao Yueting[1] ; Zhang Shao[2] ; Liu Weipeng[1] ; Li Chuanyin[1] ; Yao Yufeng[1] ; Shi Li[1] ;
机构： [1]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. [2]Department of Gynaecologic Oncology, The No. 3 Affiliated Hospital of Kunming Medical University, Kunming, China. [3]The First People's Hospital of Yunnan Province and The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China. [4]College of Nursing Health Sciences, Yunnan Open University, Kunming, China.
出处：
DOI： 10.3389/fgene.2022.856505
ISSN：

关键词： MicroRNAs Phosphatidylinositol 3 kinase Signalling pathway Single nucleotide polymorphisms Association Cervical cancer Chinese population

摘要：
Polymorphisms in microRNA (miRNA) genes could influence the expression of miRNAs that regulate the PI3K/Akt signalling pathway and play crucial roles in cancer susceptibility. To investigate the association of single nucleotide polymorphisms (SNPs) in miRNA genes of PI3K/Akt with cervical intraepithelial neoplasia (CIN) and cervical cancer (CC), nine SNPs located in miRNA genes were selected for genotyping, and the association of these SNPs with CIN and CC risk was evaluated. A total of 1,402 participants were enrolled in the current study, including 698 healthy individuals in the control group, 431 patients with CC, and 273 patients with CIN. Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. The results showed that the frequencies of rs107822 in miR-219a and rs2292832 in miR-149 were significantly different between the control and CC groups (p < 0.005). The C allele of rs107822 in miR-219a was associated with an increased risk of CC (OR = 1.29, 95%CI:1.09-1.54) whereas the C allele of rs2292832 in miR-149 was associated with a decreased risk of CC (OR = 0.77, 95%CI:0.64-0.92). The results of inheritance model analysis showed that the best-fit inheritance models for rs107822 and rs2292832 were log-additive. The 2CC + CT genotype of rs107822 could be a risk factor for CC when compared with the TT genotype (OR = 1.28, 95%CI:1.08-1.51). The 2CC + CT genotype of rs2292832 could be a protective factor against CC when compared with the TT genotype (OR = 0.76, 95%CI:0.64-0.92). However, no association of these SNPs with CIN was found in the current study. Our results suggest that rs107822 in the promoter region of miR-219a and rs2292832 in pre-miR-149 region are associated with the risk of CC.Copyright © 2022 Chen, Yan, Dong, Liang, Yao, Zhang, Liu, Li, Yao and Shi.

基金：
National Science Foundation of China [82103190]; CAMS Innovation Fund for Medical Sciences [2021-I2M-1-004]; Fundamental Research Funds for the Central Universities [3332019111]; Yunnan Province Clinical Research Center for Gynecological and Obstetric Disease [2022YJZX-FC06]; Applied Basic Research Projects of Yunnan province [202101AS070205, 202101AU070191]; Special Funds for High-level Healthy Talents of Yunnan Province [L-201615, H-2018014, D-2018037]
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 生物学
小类 | 3 区 遗传学
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 遗传学
JCR分区：
出版当年[2021]版：
Q1 GENETICS & HEREDITY
最新[2023]版：
Q2 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Kerong,Yan Zhiling,Dong Xudong,et al.Genetic Polymorphisms in microRNA Genes Targeting PI3K/Akt Signal Pathway Modulate Cervical Cancer Susceptibility in a Chinese Population.[J].FRONTIERS IN GENETICS.2022,13:doi:10.3389/fgene.2022.856505.
APA：
Chen Kerong,Yan Zhiling,Dong Xudong,Liang Yan,Yao Yueting...&Shi Li.(2022).Genetic Polymorphisms in microRNA Genes Targeting PI3K/Akt Signal Pathway Modulate Cervical Cancer Susceptibility in a Chinese Population..FRONTIERS IN GENETICS,13,
MLA：
Chen Kerong,et al."Genetic Polymorphisms in microRNA Genes Targeting PI3K/Akt Signal Pathway Modulate Cervical Cancer Susceptibility in a Chinese Population.".FRONTIERS IN GENETICS 13.(2022)

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