机构：[1]Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China[2]Jinxin Research Institute for Reproductive Medicine and Genetics, Chengdu, Jinjiang Hospital for Maternal and Child Health Care, 66 Jingxiu Road, Chengdu, China[3]Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China[4]Division of Hepatobiliary and Pancreatic Surgery, the University of Hong Kong -Shenzhen Hospital, Shenzhen, Guangdong, China[5]Department of Radiation Oncology, Affiliated Cancer Hospital, Shantou University Medical College, Shantou, Guangdong, China[6]Department of Pathology, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China[7]Department of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China[8]Department of Thoracic Surgery, Affiliated Cancer Hospital, Shantou University Medical College, Shantou, Guangdong, China[9]Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, Holland, the Netherlands
OBJECTIVES:To evaluate the occurrence, abundance, distribution, nature and clinical significance of multinucleated giant cell (MGC) in esophageal cancer.
MATERIALS AND METHODS:MGCs were examined with conventional pathology, immunohistochemistry and immunofluorescence in 107 esophageal cancer tissues. The findings were correlated to pathological diagnosis and clinical behavior of the cancers.
RESULTS:MGCs were identified in 31.7% (34/107) of the cases. MGCs were positive for CD11c, CD11b, CD32, CD16, HLA-DR and MMP9, and negative for CD163, CD206 and CD64 giving a molecular profile of proinflammatory M1 but not immunosuppressive M2. MGCs were significantly related to decreased lymph node metastasis (p = 0.011), low pTNM stage (p = 0.044), favorable survival (p = 0.04), squamous cell cancer type rather than other histopathological subtypes (p = 0.020) and associated to better differentiation (p = 0.063).
CONCLUSIONS:MGCs belong to M1 macrophage and perform phagocytosis and scavenging of cancer cells that would benefit patients' survival and could serve as a prognostic marker.
第一作者机构：[1]Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China[2]Jinxin Research Institute for Reproductive Medicine and Genetics, Chengdu, Jinjiang Hospital for Maternal and Child Health Care, 66 Jingxiu Road, Chengdu, China
推荐引用方式(GB/T 7714)：
Hui Wang,Junjie Zhou,Jun Li,et al.A study of multinucleated giant cells in esophageal cancer[J].Clinical Immunology.2021,222(2021):108600.doi:10.1016/j.clim.2020.108600.
APA：
Hui Wang,Junjie Zhou,Jun Li,Yiqun Geng,Pei Meng...&Jiang Gua.(2021).A study of multinucleated giant cells in esophageal cancer.Clinical Immunology,222,(2021)
MLA：
Hui Wang,et al."A study of multinucleated giant cells in esophageal cancer".Clinical Immunology 222..2021(2021):108600
