机构：[1]Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China[2]College of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China[3]Department of Orthopedics, 953 Hospital of PLA, Shigatse Branch of Xinqiao Hospital, Army Medical University, Shigatse, 857000, Tibet Autonomous Region, China[4]Department of Rheumatology and Immunology, Daping Hospital, Army Medical University, Chongqing, 400042, China[5]Department of Obstetrics and Gynecology, Chongqing People's Hospital, Chongqing, 401121, China[6]Department of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China[7]Department of Nuclear Medicine, the First People's Hospital of Yunnan province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650034, China
Programmed cell death 1 ligand 1 (PD-L1) is an important immunosuppressive molecule, which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell death-1. The PD-L1 expression disorder plays an important role in the occurrence, development, and treatment of sepsis or other inflammatory diseases, and has become an important target for the treatment of these diseases. Mesenchymal stem cells (MSCs) are a kind of pluripotent stem cells with multiple differentiation potential. In recent years, MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune diseases. Moreover, PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various diseases. In this review, we will summarize the main regulatory mechanism of PD-L1 expression, and discuss various biological functions of PD-L1 in the immune regulation of MSCs. (c) 2024 Production and hosting by Elsevier B.V. on behalf of Chinese Medical Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
基金：
Chongqing natural science foundation [cstc2021jcyj-msxmX1017]; Key project of science and technology in Chongqing [CSTC2021jscx-gksb-N0 026]; National Natural Science Foundation of China [32100643]
语种：
外文
WOS：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类|4 区医学
小类|4 区骨科
第一作者：
第一作者机构：[1]Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China[2]College of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China[7]Department of Nuclear Medicine, the First People's Hospital of Yunnan province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650034, China
推荐引用方式(GB/T 7714)：
Chen Zhuo,Yao Meng-Wei,Ao Xiang,et al.The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells[J].Chinese journal of traumatology.2024,27(1):1-10.doi:10.1016/j.cjtee.2023.11.003.
APA：
Chen, Zhuo,Yao, Meng-Wei,Ao, Xiang,Gong, Qing-Jia,Yang, Yi...&Zuo, Ling-Jing.(2024).The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells.Chinese journal of traumatology,27,(1)
MLA：
Chen, Zhuo,et al."The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells".Chinese journal of traumatology 27..1(2024):1-10
