机构：[1]Department of Traditional Chinese Medicine, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China[2]The Afliated Hospital of Kun ming University of Science and Technology, Kunming, Yunnan, China.[3]School of Acu Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.[4]Department of Rehabilitation, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Background
Growing evidence showed that acupuncture may improve cognitive function by reducing oxidative stress, key to the pathogenesis in vascular dementia (VaD), but this is yet to be systematically analysed. This study aimed to summarize and evaluate the effect of acupuncture on oxidative stress in animal models of VaD.
Method
Eight databases including PubMed, Embase, Web of Science, Cochrane library, CNKI, Wan Fang, CBM, and VIP were searched since their establishment until April 2023, for studies that reported the effect of acupuncture on oxidative stress in VaD animal models. Relevant literature was screened, and information was extracted by two reviewers. The primary outcomes were the levels of oxidative stress indicators. The methodological quality was assessed via the SYRCLE Risk of Bias Tool. Statistical analyses were performed using the RevMan and Stata software.
Results
In total, 22 studies with 747 animals were included. The methodology of most studies had flaws or uncertainties. The meta-analysis indicated that, overall, acupuncture significantly reduced the expression of pro-oxidants including reactive oxygen species (standardized mean differences [SMDs] = -4.29, 95% confidence interval [CI]: -6.26, -2.31), malondialdehyde (SMD = -2.27, 95% CI: -3.07, -1.47), nitric oxide (SMD = -0.85, 95% CI: -1.50, -0.20), and nitric oxide synthase (SMD = -1.01, 95% CI: -1.69, -0.34) and enhanced the levels of anti-oxidants including super oxide dismutase (SMD = 2.80, 95% CI: 1.98, 3.61), glutathione peroxidase (SMD = 1.32, 95% CI: -0.11, 2.76), and catalase (SMD = 1.31, 95% CI: 0.05, 2.58) in VaD animal models. In subgroup analyses, acupuncture showed significant effects on most variables. Only partial modelling methods and treatment duration could interpret the heterogeneity of some outcomes.
Conclusion
Acupuncture may inhibit oxidative stress to improve cognitive deficits in animal models of VaD. Nevertheless, the methodological quality is unsatisfactory. More high-quality research with a rigorous design and further experimental researches and clinical trials are needed to confirm these findings.
第一作者机构：[1]Department of Traditional Chinese Medicine, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China[2]The Afliated Hospital of Kun ming University of Science and Technology, Kunming, Yunnan, China.[3]School of Acu Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Traditional Chinese Medicine, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China[2]The Afliated Hospital of Kun ming University of Science and Technology, Kunming, Yunnan, China.
推荐引用方式(GB/T 7714)：
Qiong‑Nan Bao,Man‑Ze Xia,Jing Xiong,et al.The effect of acupuncture on oxidative stress in animal models of vascular dementia: a systematic review and meta-analysis[J].Systematic reviews.2024,13(59):doi:10.1186/s13643-024-02463-x.
APA：
Qiong‑Nan Bao,Man‑Ze Xia,Jing Xiong,Yi‑Wei Liu,Ya‑Qin Li...&Fan‑Rong Liang.(2024).The effect of acupuncture on oxidative stress in animal models of vascular dementia: a systematic review and meta-analysis.Systematic reviews,13,(59)
MLA：
Qiong‑Nan Bao,et al."The effect of acupuncture on oxidative stress in animal models of vascular dementia: a systematic review and meta-analysis".Systematic reviews 13..59(2024)
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