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Whole genome analysis identifies intra-serotype recombinants and positive selection sites of dengue virus in mainland China from 2015 to 2020

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资源类型：
Pubmed体系：
作者：
Zhu Xiaoli[1,2,3] * ; Chen Wanxin[1] * ; Ma Chunli[2] ; Wang Xin[2] ; Sun Jing[1] ; Nie Jianyun[2,3,*1] ; Shi Jiandong[1,*1] ; Hu Yunzhang[1,*1] ;
机构： [1]Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China [2]Kunming Medical University, Kunming, Yunnan, China [3]Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
出处：
DOI： 10.1016/j.virusres.2022.198705
ISSN：

关键词： Dengue virus (DENV) Recombination Positive selection Surveillance

摘要：
Immune pressure can select for escape mutants that can become epidemiologically relevant. Thus, surveillance of recombinants and positively selected mutants of the dengue virus (DENV) are vital for preventing and controlling the dengue fever outbreak. However, little is known about recombinants and positively selected mutants of circulating DENV strains in mainland China. In this study, those variants with recombination and adaptive evolutionary sites of circulating DENV strains were identified during 2015-2020. Phylogenetic analysis showed that the DENV-2 was the dominant epidemic serotype, and the dengue epidemic in China was closely related to the imported virus from Southeast Asian countries. Recombination analysis based on 291 complete genomes of naturally circulating DENV identified 10 new intra-serotype recombinant variants. Two or three recombination regions in a single dengue isolate were also observed. The breakpoints of recombinants were distributed in different regions of the genome. In particular, two recombinant strains (strain DENV-4/China/YN/15DGR394 (2015) and XLLM10666) with extremely large exchange fragments were detected. This large-scale gene fragment exchange (eight genomic regions) of strain DENV-4/China/YN/15DGR394 (2015) with substitutions at both the 5' and 3' ends of the genome, had never been described before. Moreover, selection pressure analyses revealed seven positive selection sites located in regions encoding the NS1, NS3 and NS5 proteins. Overall, this study is the first to report ten specific intra-serotype recombinants and seven positive selection sites of Chinese epidemic strains of DENV, which highlight their significance for DENV surveillance and effective control.Copyright © 2022. Published by Elsevier B.V.

基金：
This study was supported by the Innovation Team Project of Yunnan Science and Technology Department (202105AE160020), the Applied Basic Research Key Project of Yunnan (CN) (202001AS070046), the Fund for Reserve Talents of Young and Middle-aged Academic and Technical Leaders of Yunnan Province (2019HB043), and the National Natural Science Foundation of China (No. 81760480).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 病毒学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 病毒学
第一作者：
第一作者机构： [1]Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China [2]Kunming Medical University, Kunming, Yunnan, China [3]Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
共同第一作者：
通讯作者：
通讯机构： [1]Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China [2]Kunming Medical University, Kunming, Yunnan, China [3]Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China [*1]935 Jiaoling Road, Kunming, Yunnan Province 650118 China
推荐引用方式(GB/T 7714)：
Zhu Xiaoli,Chen Wanxin,Ma Chunli,et al.Whole genome analysis identifies intra-serotype recombinants and positive selection sites of dengue virus in mainland China from 2015 to 2020[J].Virus research.2022,311:198705.doi:10.1016/j.virusres.2022.198705.
APA：
Zhu Xiaoli,Chen Wanxin,Ma Chunli,Wang Xin,Sun Jing...&Hu Yunzhang.(2022).Whole genome analysis identifies intra-serotype recombinants and positive selection sites of dengue virus in mainland China from 2015 to 2020.Virus research,311,
MLA：
Zhu Xiaoli,et al."Whole genome analysis identifies intra-serotype recombinants and positive selection sites of dengue virus in mainland China from 2015 to 2020".Virus research 311.(2022):198705

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