Score for the Risk and Overall Survival of Lung Metastasis in Patients First Diagnosed With Soft Tissue Sarcoma: A Novel Nomogram-Based Risk Assessment System
机构:[1]The People's Hospital of Lishui, Lishui, Zhejiang, 323000, China.[2]Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China.[3]The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China.[4]The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, 323000, China.
Background: Metastatic soft tissue sarcoma (STS) patients have a poor prognosis with a 3-year survival rate of 25%. About 30% of them present lung metastases (LM). This study aimed to construct 2 nomograms to predict the risk of LM and overall survival of STS patients with LM. Materials and Methods: The data of patients were derived from the Surveillance, Epidemiology, and End Results database during the period of 2010 to 2015. Logistic and Cox analysis was performed to determine the independent risk factors and prognostic factors of STS patients with LM, respectively. Afterward, 2 nomograms were, respectively, established based on these factors. The performance of the developed nomogram was evaluated with receiver operating characteristic curves, area under the curve (AUC) calibration curves, and decision curve analysis (DCA). Results: A total of 7643 patients with STS were included in this study. The independent predictors of LM in first-diagnosed STS patients were N stage, grade, histologic type, and tumor size. The independent prognostic factors for STS patients with LM were age, N stage, surgery, and chemotherapy. The AUCs of the diagnostic nomogram were 0.806 in the training set and 0.799 in the testing set. For the prognostic nomogram, the time-dependent AUC values of the training and testing set suggested a favorable performance and discrimination of the nomogram. The 1-, 2-, and 3-year AUC values were 0.698, 0.718, and 0.715 in the training set, and 0.669, 0.612, and 0717 in the testing set, respectively. Furthermore, for the 2 nomograms, calibration curves indicated satisfactory agreement between prediction and actual survival, and DCA indicated its clinical usefulness. Conclusion: In this study, grade, histology, N stage, and tumor size were identified as independent risk factors of LM in STS patients, age, chemotherapy surgery, and N stage were identified as independent prognostic factors of STS patients with LM, these developed nomograms may be an effective tool for accurately predicting the risk and prognosis of newly diagnosed patients with LM.
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外文
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出版当年[2022]版:
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版:
大类|4 区医学
小类|4 区肿瘤学
第一作者:
第一作者机构:[1]The People's Hospital of Lishui, Lishui, Zhejiang, 323000, China.[2]Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China.
通讯作者:
通讯机构:[1]The People's Hospital of Lishui, Lishui, Zhejiang, 323000, China.[4]The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, 323000, China.[*1]The People’s Hospital of Lishui, No.15 Dazhong St, Liandu District, Lishui, Zhejiang 323000, China
推荐引用方式(GB/T 7714):
Fan Zhiyi,Chi Changxing,Tong Yuexin,et al.Score for the Risk and Overall Survival of Lung Metastasis in Patients First Diagnosed With Soft Tissue Sarcoma: A Novel Nomogram-Based Risk Assessment System[J].Technology in cancer research & treatment.2022,21:15330338211066240.doi:10.1177/15330338211066240.
APA:
Fan Zhiyi,Chi Changxing,Tong Yuexin,Huang Zhangheng,Song Youxin&You Shengjie.(2022).Score for the Risk and Overall Survival of Lung Metastasis in Patients First Diagnosed With Soft Tissue Sarcoma: A Novel Nomogram-Based Risk Assessment System.Technology in cancer research & treatment,21,
MLA:
Fan Zhiyi,et al."Score for the Risk and Overall Survival of Lung Metastasis in Patients First Diagnosed With Soft Tissue Sarcoma: A Novel Nomogram-Based Risk Assessment System".Technology in cancer research & treatment 21.(2022):15330338211066240