机构：[1]Department of Laboratory Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China[2]Department of Vascular Surgery, Fuwai Yunnan Cardiovascular Hospital, Kunming Medical University, Kunming 650000, China
The aim of this study was to explore the diagnostic efficiency of serum exosomal miR-451a as a novel biomarker for pancreatic cancer.Serum samples were collected prior to treatment. First, we analyzed microRNA (miRNA) profiles in serum exosomes from eight pancreatic cancer patients and eight healthy volunteers. We then validated the usefulness of the selected exosomal miRNAs as biomarkers in another 191 pancreatic cancer patients, 95 pancreatic benign disease (PB) patients, and 90 healthy controls.The expression of miR-451a in serum-derived exosomes from pancreatic cancer patients was significantly upregulated compared with those from PB patients and healthy individuals. Serum exosomal miR-451a showed excellent diagnostic power in identifying pancreatic cancer patients. In addition, exosomal miR-451a showed a significant association with clinical stage and distant metastasis in pancreatic cancer, and the expression level of serum exosomal miR-451a was sensitive to therapy and relapse.Serum exosomal miR-451a might serve as a novel diagnostic marker for pancreatic cancer.
基金：
The Research Foundation of The National Clinical Research Base
of Traditional Chinese Medicine of Longhua Hospital (No.
Seedling program LYTD-73); The Innovation Project of
Longhua Hospital (No. CX202058); The Applied Basic
Research Programs of Science and Technology Commission
Foundation of Yunnan Provincial and Kunming Medical
University (No. 2019FE001(-109)); The Open Subject of State
Key Laboratory of Cardiovascular Disease of Fuwai Hospital
(No. 2019kfyf-03, 2019kfyf-04); and The National Natural
Science Foundation of China (No. 81803893).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Laboratory Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Laboratory Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China[2]Department of Vascular Surgery, Fuwai Yunnan Cardiovascular Hospital, Kunming Medical University, Kunming 650000, China[*1]Department of Vascular Surgery, Fuwai Yunnan Cardiovascular Hospital, Kunming Medical University, No. 528 Shahe North Road, Kunming, 650000, China[*2]Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China
推荐引用方式(GB/T 7714)：
Chen Jia,Yao Dongting,Chen Weiqin,et al.Serum exosomal miR-451a acts as a candidate marker for pancreatic cancer[J].The International journal of biological markers.2022,37(1):74-80.doi:10.1177/17246008211070018.
APA：
Chen Jia,Yao Dongting,Chen Weiqin,Li Zhen,Guo Yuanyuan...&Hu Xiaobo.(2022).Serum exosomal miR-451a acts as a candidate marker for pancreatic cancer.The International journal of biological markers,37,(1)
MLA：
Chen Jia,et al."Serum exosomal miR-451a acts as a candidate marker for pancreatic cancer".The International journal of biological markers 37..1(2022):74-80
