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Upregulation of Orai1 and increased calcium entry contribute to angiotensin II-induced human coronary smooth muscle cell proliferation: Running Title: Angiotensin II-induced human coronary smooth muscle cells proliferation

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资源类型：
Pubmed体系：
作者：
Liu Bei[1] * ; Zhang Bin[2] * ; Roos Carolyn M[2] ; Zeng Wenjun[1] ; Zhang Haiping[1] ; Guo Ruiwei[1,*1] ;
机构： [1]Department of Cardiology, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, Yunnan, 650032, China. [2]Division of Cardiovascular Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
出处：
DOI： 10.1016/j.peptides.2020.170386
ISSN：

关键词： Angiotensin II human coronary smooth muscle cells store-operated Ca2+channel orai1 NF-κB

摘要：
Angiotensin II (Ang II) is an oligopeptide of the renin-angiotensin system, and Ang II-induced vascular smooth muscle cell (VSMC) proliferation is an important pathophysiological process involved in atherosclerosis; however, the underlying mechanism remains unclear. Orai1 and Stim1 are the main components of store-operated Ca2+ entry (SOCE), which has an important effect on VSMC proliferation. In the present study, we showed that Ang II-induced human coronary smooth muscle cell (HCSMC) proliferation was associated with increased calcium entry. The expression of Orai1, but not that of Stim1, was significantly upregulated in Ang II-treated HCSMCs. However, knockdown of Orai1 or Stim1 decreased HCSMC proliferation and SOCE activity in Ang II-treated HCSMCs. Orai1 was significantly downregulated in HCSMCs transfected with short interfering RNA (siRNA) against NOX2 or NF-κB. Transfection with siRNA against NOX2 or p65 also decreased Ang II-induced HCSMCs SOCE activation and proliferation. These findings suggested that Ang II upregulated Orai1 via the NF-κB and NOX2 pathways, leading to increased SOCE and HCSMC proliferation. The molecular factors mediating Ang II-induced SOCE upregulation are potential therapeutic targets for the prevention of Ang II-sensitive or Ang II-dependent HCSMC proliferation.Copyright © 2020 Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China Grant (number 81370383).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 药学 4 区 生化与分子生物学 4 区 内分泌学与代谢
最新[2023]版：
大类 | 4 区 医学
小类 | 3 区 药学 4 区 生化与分子生物学 4 区 内分泌学与代谢
第一作者：
第一作者机构： [1]Department of Cardiology, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, Yunnan, 650032, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Cardiology, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, Yunnan, 650032, China. [*1]Department of Cardiology, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, Yunnan, 650032, China
推荐引用方式(GB/T 7714)：
Liu Bei,Zhang Bin,Roos Carolyn M,et al.Upregulation of Orai1 and increased calcium entry contribute to angiotensin II-induced human coronary smooth muscle cell proliferation: Running Title: Angiotensin II-induced human coronary smooth muscle cells proliferation[J].Peptides.2020,133:170386.doi:10.1016/j.peptides.2020.170386.
APA：
Liu Bei,Zhang Bin,Roos Carolyn M,Zeng Wenjun,Zhang Haiping&Guo Ruiwei.(2020).Upregulation of Orai1 and increased calcium entry contribute to angiotensin II-induced human coronary smooth muscle cell proliferation: Running Title: Angiotensin II-induced human coronary smooth muscle cells proliferation.Peptides,133,
MLA：
Liu Bei,et al."Upregulation of Orai1 and increased calcium entry contribute to angiotensin II-induced human coronary smooth muscle cell proliferation: Running Title: Angiotensin II-induced human coronary smooth muscle cells proliferation".Peptides 133.(2020):170386

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