机构：[1]School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China.[2]Yunnan College of Business Management, Kunming, Yunnan, China.[3]Department of Critical Care Medicine, Weinan First Hospital, Weinan, Shaanxi, China.[4]Department of Gastroenterology, The Third People's Hospital of Datong, Datong, Shanxi, China.[5]Department of General Surgery, Yuquan Hospital of Tsinghua University, Beijing, China.
Age-related fibrosis is attenuated by aerobic exercise; however, little is known concerning the underlying molecular mechanism. To address this question, aged rats were given moderate-intensity exercise for 12 weeks. After exercise in aged rats, hydrogen sulfide levels in plasma and heart increased 39.8% and 90.9%, respectively. Exercise upregulated expression of cystathionine γ-lyase and 3-mercaptopyruvate sulfurtransferase in heart of aged rats. Furthermore, aged rats were given moderate-intensity exercise for 12 weeks or treated with NaHS (intraperitoneal injection of 0.1 mL/kg per day of 0.28 mol/L NaHS). After exercise in aged rats, Masson-trichrome staining area decreased 34.8% and myocardial hydroxyproline levels decreased 29.6%. Exercise downregulated expression of collagen-I and α- smooth muscle actin in heart of aged rats. Exercise in aged rats reduced malondialdehyde levels in plasma and heart and 3-nitrotyrosine in heart. Exercise in aged rats reduced mRNA and protein expression of C/EBP homologous protein, glucose regulated protein 78, and X-box protein 1. Exercise also reduced mRNA and protein expression of interleukin 6 and monocyte chemotactic protein 1and suppressed activation of c-Jun N-terminal kinase in aging heart. Similar effects were demonstrated in aged rats treated with NaHS. Collectively, exercise restored bioavailability of hydrogen sulfide in the heart of aged rats, which partly explained the benefits of exercise against myocardial fibrosis of aged population.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区药学4 区生理学
最新[2023]版：
大类|4 区医学
小类|4 区药学4 区生理学
第一作者：
第一作者机构：[1]School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China.[*1]Shaanxi normal university, West Chang'an Avenue 620,Chang'an District, Xi'an, Shaanxi, 710119, China
通讯作者：
通讯机构：[1]School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China.[2]Yunnan College of Business Management, Kunming, Yunnan, China.[*1]Shaanxi normal university, West Chang'an Avenue 620,Chang'an District, Xi'an, Shaanxi, 710119, China[*2]Yunnan college of business management, Haitun Road 296, Kunming, Yunnan Province, 650106,China
推荐引用方式(GB/T 7714)：
Ma Ning,Liu Hong-Mei,Xia Ting,et al.Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide[J].Canadian journal of physiology and pharmacology.2018,96(9):902-908.doi:10.1139/cjpp-2018-0153.
APA：
Ma Ning,Liu Hong-Mei,Xia Ting,Liu Jian-Dong&Wang Xiao-Ze.(2018).Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide.Canadian journal of physiology and pharmacology,96,(9)
MLA：
Ma Ning,et al."Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide".Canadian journal of physiology and pharmacology 96..9(2018):902-908
