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Sequential anti-inflammatory and osteogenic effects of a dual drug delivery scaffold loaded with parthenolide and naringin in periodontitis

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机构: [1]Department of Stomatology, The First People’s Hospital of Yunnan Province, Kunming, China [2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China [3]Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, China [4]Jinan University, Guangzhou, China
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关键词: Periodontitis naringin parthenolide Drug delivery systems

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Our pilot study showed that a 3-dimensional dual drug delivery scaffold (DDDS) loaded with Chinese herbs significantly increased the regenerated bone volume fraction. This study aimed to confirm the synergistic anti-inflammatory and osteogenic preclinical effects of this system.The targets and pathways of parthenolide and naringin were predicted. Three cell models were used to assess the anti-inflammatory effects of parthenolide and the osteogenic effects of naringin. First, the distance between the cementoenamel junction and alveolar bone crest (CEJ-ABC) and the bone mineral density (BMD) of surgical defects were measured in a rat model of periodontitis with periodontal fenestration defects. Additionally, the mRNA expression levels of matrix metallopeptidase 9 (MMP9) and alkaline phosphatase (ALP) were measured. Furthermore, the number of inflammatory cells and osteoclasts, as well as the protein expression levels of tumor necrosis factor-alpha (TNF-α) and levels of ALP were determined.Target prediction suggested prostaglandin peroxidase synthase (PTGS2) as a potential target of parthenolide, while cytochrome P450 family 19 subfamily A1 (CYP19A1) and taste 2 receptor member 31 (TAS2R31) were potential targets of naringin. Parthenolide mainly targeted inflammation-related pathways, while naringin participated in steroid hormone synthesis and taste transduction. In vitro experiments revealed significant anti-inflammatory effects of parthenolide on RAW264.7 cells, and significant osteogenic effects of naringin on bone marrow mesenchymal stem cells and MC3T3-E1 cells. DDDS loaded with parthenolide and naringin decreased the CEJ-ABC distance and increased BMD and ALP levels in a time-dependent manner. Inflammation was significantly alleviated after 14 days of DDDS treatment. Additionally, after 56 days, the DDDS group exhibited the highest BMD and ALP levels.DDDS loaded with parthenolide and naringin in a rat model achieved significant synergistic anti-inflammatory and osteogenic effects, providing powerful preclinical evidence.Copyright © 2022. Korean Academy of Periodontology.

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出版当年[2023]版:
大类 | 4 区 医学
小类 | 4 区 牙科与口腔外科
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 牙科与口腔外科
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出版当年[2022]版:
Q4 DENTISTRY, ORAL SURGERY & MEDICINE
最新[2023]版:
Q2 DENTISTRY, ORAL SURGERY & MEDICINE

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第一作者机构: [1]Department of Stomatology, The First People’s Hospital of Yunnan Province, Kunming, China [2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China
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通讯机构: [1]Department of Stomatology, The First People’s Hospital of Yunnan Province, Kunming, China [2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China [*1]Department of Stomatology, The First People’s Hospital of Yunnan Province, No. 157 Jinbi Street, Kunming, Yunnan 650032, China.
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