机构：[1]Department of Radiology, The First People’s Hospital of Yunnan Province, Xishan District, Kunming, Yunnan, China医技片放射科云南省第一人民医院[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China云南省第一人民医院[3]Kunming Medical University, Chenggong District, Kunming, Yunnan, China[4]The Third People’s Hospital of Yunnan Province, Guandu District, Kunming, Yunnan, China
Introduction:Measurement of biomarkers early after acute myocardial infarction (AMI) might provide a cost-effective and widely available tool to assess infarct severity, myocardial dysfunction, and clinical outcomes. We aimed to induce AMI in miniature pigs, measure the levels of serum biomarkers and global LV function dynamically and explore the release kinetics and optimal sampling time points of copeptin and its correlation with global LV function. Methods:We induced AMI in the experimental group using a closed-chest model. Left ventricular (LV) function was detected by dual-source computed tomography (DSCT) and serum copeptin was determined by ELISA. Results:The serum copeptin levels were increased at 1 hour, peaked at 3 hours, gradually decreased after 6 hours, and returned to baseline 3 days after AMI. At 3 to 6 hours, the copeptin cutoff of 16.97 to 17.44 pmol/l had 100% sensitivity and 100% specificity (P <= .001) for AMI. Serum copeptin levels at 3 hours and 3 days were negatively correlated with the 3-hours LVEF (P <= .001), respectively. Conclusion:Serum copeptin levels change in time, and measurements at 3 to 6 hours after AMI had the highest predictive value.
第一作者机构：[1]Department of Radiology, The First People’s Hospital of Yunnan Province, Xishan District, Kunming, Yunnan, China[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
共同第一作者：
通讯作者：
通讯机构：[4]The Third People’s Hospital of Yunnan Province, Guandu District, Kunming, Yunnan, China[*1]Department of Radiology, The Third People’s Hospital of Yunnan Province, 292, Beijing Road, Guandu District, Kunming, Yunnan 650011, China
推荐引用方式(GB/T 7714)：
Li Wenjia,Sun Wenjian,Lyu Liang,et al.Copeptin Reflect Left Ventricular Systolic Function at Early Stage of Acute Myocardial Infarction in a Pig Model[J].BIOMARKER INSIGHTS.2023,18:doi:10.1177/11772719231171764.
APA：
Li, Wenjia,Sun, Wenjian,Lyu, Liang,Wang, Gang,Yang, Weixin...&Zhang, Rongshun.(2023).Copeptin Reflect Left Ventricular Systolic Function at Early Stage of Acute Myocardial Infarction in a Pig Model.BIOMARKER INSIGHTS,18,
MLA：
Li, Wenjia,et al."Copeptin Reflect Left Ventricular Systolic Function at Early Stage of Acute Myocardial Infarction in a Pig Model".BIOMARKER INSIGHTS 18.(2023)
