机构：[1]Department of Cardiology, Guangdong Provincial Key Laboratory of CoronaryHeart Disease Prevention, Guangdong Cardiovascular Institute, GuangdongProvincial People’s Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510080, China广东省人民医院[2]Department of Endocrinology, Longyan FirstAffiliated Hospital of Fujian Medical University, Longyan 364000, China[3]TheSecond School of Clinical Medicine, Southern Medical University, Guangzhou510515, China[4]Department of Cardiology, Maoming People’s Hospital,Maoming 525000, China[5]Kunming Medical University, Kunming 650500,China[6]Department of Ultrasound Imaging, Yunnan Fuwai CardiovascularHospital, Kunming 650500, China[7]Guangdong Provincial People’s Hospital,School of Medicine, South China University of Technology, Guangzhou510100, China[8]Department of Cardiology, Longyan First AffiliatedHospital of Fujian Medical University, Longyan 364000, China
Background Predictive value of creatine kinase MB (CK-MB) for contrast-induced acute kidney injury (CI-AKI) among myocardial infarction (MI) patients has rarely been reported. We aim to evaluate the predictive value of CK-MB for CI-AKI among MI patients. Methods Totally, 1131 MI patients were included from the REduction of rIsk for Contrast-Induced Nephropathy (REICIN) study. The peak CK-MB before coronary angiography (CAG) was chosen. The study population was divided into two groups by log-transformed CK-MB cut-off point. The association between CK-MB and CI-AKI was tested by multivariable logistic regression. CK-MB was integrated with Age, creatinine and ejection fraction (ACEF) score and Mehran risk score (MRS) to evaluate the additive value of CK-MB. The integrated models were validated internally by the bootstrap method and externally by the PREdictive Value of COntrast voluMe to creatinine Clearance Ratio (PRECOMIN) study data set. Results Overall, 62(5.48%) patients developed CI-AKI, patients with CK-MB point > 4.7 displayed a higher incidence of CI-AKI than those without (11.9% vs. 4.0%, p < 0.001). CK-MB point > 4.7 was independently associated with CI-AKI (adjusted OR: 3.40, 95% CI: 1.93-5.98, p < 0.001). The additions of CK-MB to ACEF score, Mehran score A and Mehran score B resulted in increases in C-statistics, which ranged from 0.680 to 0.733 (p = 0.046), 0.694 to 0.727 (p = 0.091), 0.704 to 0.734 (p = 0.102), respectively. Internal validation also showed increases in C-statistics, and external validation performed well in discrimination and calibration. Conclusions Preprocedural peak CK-MB was a predictor of CI-AKI among MI patients.
基金：
Beijing Lisheng Cardiovascular
Health Foundation and Guangdong Provincial People’s Hospital Foundation
(LHJJ20141751), National Science Foundation of China (81970311), Guangdong
Provincial Science and Technology Plan Project (2017B030314041) and
Guangdong Provincial Fund for Clinical Medications (2019ZH01)
第一作者机构：[1]Department of Cardiology, Guangdong Provincial Key Laboratory of CoronaryHeart Disease Prevention, Guangdong Cardiovascular Institute, GuangdongProvincial People’s Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510080, China[2]Department of Endocrinology, Longyan FirstAffiliated Hospital of Fujian Medical University, Longyan 364000, China[3]TheSecond School of Clinical Medicine, Southern Medical University, Guangzhou510515, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wei Wen,Zhang Lingyu,Zhang Yunhan,et al.Predictive value of creatine kinase MB for contrast-induced acute kidney injury among myocardial infarction patients[J].BMC CARDIOVASCULAR DISORDERS.2021,21(1):doi:10.1186/s12872-021-02155-7.
APA：
Wei, Wen,Zhang, Lingyu,Zhang, Yunhan,Tang, Ronghui,Zhao, Miao...&Chen, Shiqun.(2021).Predictive value of creatine kinase MB for contrast-induced acute kidney injury among myocardial infarction patients.BMC CARDIOVASCULAR DISORDERS,21,(1)
MLA：
Wei, Wen,et al."Predictive value of creatine kinase MB for contrast-induced acute kidney injury among myocardial infarction patients".BMC CARDIOVASCULAR DISORDERS 21..1(2021)
