机构：[1]Department of Hematology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China内科片血液内科云南省第一人民医院[2]Emergency of Department, Yunnan Provincial Hospital of Traditional Chinese Medicine, The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China[3]Yunnan Province Clinical Center for Hematologic Disease, The First People’s Hospital of Yunnan Province, Kunming, China云南省第一人民医院[4]Yunnan Blood Disease Hospital, The First People’s Hospital of Yunnan Province, Kunming, China云南省第一人民医院[5]National Key Clinical Specialty of Hematology, The First People’s Hospital of Yunnan Province, Kunming, China云南省第一人民医院[6]Yunnan Province Clinical Research Center for Hematologic Disease, The First People’s Hospital of Yunnan Province, Kunming, China云南省第一人民医院[7]Department of Oral and maxillofacial surgery, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China外科片口腔颌面外科云南省第一人民医院
Graft-versus-host disease (GVHD) is one of the most important cause of death in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). The gastrointestinal tract is one of the most common sites affected by GVHD. However, there is no gold standard clinical practice for diagnosing gastrointestinal GVHD (GIGVHD), and it is mainly diagnosed by the patient's clinical symptoms and related histological changes. Additionally, GI-GVHD causes intestinal immune system disorders, damages intestinal epithelial tissue such as intestinal epithelial cells((IEC), goblet, Paneth, and intestinal stem cells, and disrupts the intestinal epithelium's physical and chemical mucosal barriers. The use of antibiotics and diet alterations significantly reduces intestinal microbial diversity, further reducing bacterial metabolites such as short-chain fatty acids and indole, aggravating infection, and GI-GVHD. gut microbe diversity can be restored by fecal microbiota transplantation (FMT) to treat refractory GI-GVHD. This review article focuses on the clinical diagnosis of GI-GVHD and the effect of GVHD on intestinal flora and its metabolites.
基金：
Project of Yunnan Blood Disease Clinical Medical Center [2020LCZXKF-XY18, 2021LCZXXF-XY09, 2022LCZXKF-XY01]; Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Special Project on Applied Basic Research [202301AY070001-064, 202101AY070001-273]
第一作者机构：[1]Department of Hematology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Hematology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China[3]Yunnan Province Clinical Center for Hematologic Disease, The First People’s Hospital of Yunnan Province, Kunming, China[4]Yunnan Blood Disease Hospital, The First People’s Hospital of Yunnan Province, Kunming, China[5]National Key Clinical Specialty of Hematology, The First People’s Hospital of Yunnan Province, Kunming, China[6]Yunnan Province Clinical Research Center for Hematologic Disease, The First People’s Hospital of Yunnan Province, Kunming, China[*1]Department of Hematology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming 650032, China
推荐引用方式(GB/T 7714)：
Ji Hao,Feng Shuai,Liu Yuan,et al.Effect of GVHD on the gut and intestinal microflora[J].TRANSPLANT IMMUNOLOGY.2024,82:doi:10.1016/j.trim.2023.101977.
APA：
Ji, Hao,Feng, Shuai,Liu, Yuan,Cao, Yue,Lou, Huiquan&Li, Zengzheng.(2024).Effect of GVHD on the gut and intestinal microflora.TRANSPLANT IMMUNOLOGY,82,
MLA：
Ji, Hao,et al."Effect of GVHD on the gut and intestinal microflora".TRANSPLANT IMMUNOLOGY 82.(2024)
